BioCentury | Sep 14, 2018
Product R&D

Academia’s manufacturing problem

...source of Odylia’s other four disclosed programs, which deliver the genes USH1C, USH2A, RDH12 and CLRN1...
...Drug Administration (FDA), Silver Spring, Md. Usher 2020 Foundation Inc., Atlanta, Ga. Targets CLRN1 - Clarin 1...
BioCentury | Jul 17, 2018
Distillery Therapeutics

Otologic

...INDICATION: Hearing loss Mouse studies suggest CLRN1 gene therapy could help treat hearing loss in Usher...
...cell-specific CLRN1 knockout mouse model of Usher syndrome type 3A, intracochlear injection of a mouse CLRN1...
...treatment. In a systemic CLRN1 knockout mouse model of the syndrome, intracochlear injection of the CLRN1-encoding...
BioCentury | Apr 28, 2016
Distillery Therapeutics

Therapeutics: Clarin 1 (CLRN1)

...Other INDICATION: Hearing loss In vitro and mouse studies identified a CLRN1 protein stabilizer that could...
...III. High throughput screening of a small molecule library in mouse fibroblasts expressing mutant human CLRN1...
...Next steps could include testing the compound's effect on other symptoms of Usher syndrome. TARGET/MARKER/PATHWAY: Clarin 1 (CLRN1)...
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