16:43 , Apr 17, 2018 |  BC Extra  |  Preclinical News

New protein complex sensitizes cancers to PARP inhibitors

Researchers at University of Copenhagen and colleagues used a network-based proteomics approach to identify shieldin, a protein complex that sensitizes BRCA1-deficient cancers to PARP inhibitors, suggesting that shieldin component levels could guide precision medicine strategies. In...