BioCentury | Nov 30, 2018
Targets & Mechanisms

Adhesion targets emerge at ASH 2018

...B-cell prolymphocytic leukemia. Institut National de la Sante et de la Recherche Medicale (INSERM) 943 Chromodomain helicase DNA binding protein 2 (CHD2)...
BioCentury | Feb 23, 2017
Translation in Brief

Just the essentials

A team led by University of Texas MD Anderson Cancer Center President Ronald DePinho has developed a method of scouring cancer genome databases for new targets by looking for what he calls "the ghosts of...
BioCentury | Feb 22, 2017
Distillery Techniques

Assays and screens

TECHNOLOGY: Bioinformatics screens A bioinformatics method of screening for synthetically lethal gene pairs could help identify new targets to treat cancer. The method involved scanning cancer databases to identify pairs of genes for which deletion...
BioCentury | Dec 6, 2016
Distillery Therapeutics

Cancer

INDICATION: Sarcoma Cell culture studies suggest inhibiting CHD4 could help treat PAX-FOX1 fusion gene -positive rhabdomyosarcomas. In two human rhabdomyosarcoma cell lines positive for the PAX-FOX1 fusion oncogene, shRNA targeting CHD4 decreased cell numbers and...
BioCentury | Apr 14, 2016
Product R&D

AACR by the numbers

See Figure: Top indications See Table: Novel cancer targets at AACR 2016 See Figure: Top institutions and companies See Figure: Top targets Tables Novel cancer targets at AACR 2016 Breast cancer amplified sequence 1 (BCAS1)...
BioCentury | Jul 17, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Brain cancer Chromodomain helicase DNA binding protein 5 (CHD5) Studies in cell culture and in mice suggest that activation or...
BioCentury | Feb 10, 2007
Clinical News

Protein implicated as tumor suppressor

Researchers from Cold Spring Harbor Laboratory and colleagues published in Cell that a gene encoding chromodomain helicase DNA binding protein 5 (Chd5) serves as a tumor suppressor, a previously unrecognized role for the protein. The...
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