BioCentury | Apr 16, 2019
Preclinical News

Mounting a mitochondrial attack to starve the inflammasome

...tool compound CHKA inhibitors increased mitophagy and decreased secretion of IL-1β compared with vehicle. The CHKA...
...axis. The UCSD group is filing a patent to use genetic or chemical inhibitors of CHKA...
...last month (see “Novintum: Bugging Cancer” ; “A Mitochondrial Shield From Cell Death” ). Targets: CHKA...
BioCentury | Feb 13, 2014
Distillery Therapeutics

Indication: Cancer

...studies identified a CHKA inhibitor that could help treat cancers. An asymmetrical, biscationic inhibitor of CHKA...
...the choline-binding site exclusively and opens an adjacent binding site had about 200-fold selectivity for CHKA...
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