BC Innovations | May 15, 2018
Distillery Therapeutics

Autoimmune disease

INDICATION: Arthritis In vitro and mouse studies identified a chemokine-targeting single-chain variable fragment (scFv)-based fusion protein that could help treat arthritis. Screening of a scFv library for binding to various human and mouse chemokines, engineering...
BioCentury | Apr 13, 2018
Tools & Techniques

Personalizing prevention

PlaqueTec Ltd. is working to bring personalized medicine to the cardiovascular space with a device that samples local concentrations of molecules near atherosclerotic plaques. By using these samples to identify prognostic and predictive biomarkers, the...
BC Innovations | Jan 21, 2016
Distillery Therapeutics

Therapeutics: CXC chemokine receptor 2 (CXCR2; IL8RB); chemokine CXC motif ligand 5 (CXCL5; ENA78)

Cancer INDICATION: Prostate cancer Mouse and cell culture studies suggest CXCR2 inhibitors could help treat invasive prostate cancer. In a mouse model of highly invasive prostate cancer, tumor levels of CXCL5 and CXCR2-expressing myeloid-derived suppressor...
BC Innovations | Mar 5, 2015
Distillery Techniques

Techniques: Diagnostic markers of relapsing multiple sclerosis (MS)

Biomarkers TECHNOLOGY: Plasma markers Plasma levels of neutrophil-related proteins could help diagnose relapsing MS. In presymptomatic mouse models of experimental autoimmune encephalomyelitis, the numbers of disease-promoting neutrophils in the CNS and plasma, and levels of...
BC Innovations | Feb 27, 2014
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Tuberculosis Chemokine CXC motif ligand 5 (CXCL5; ENA78); CXC chemokine receptor 2 (CXCR2; IL8RB) Mouse studies suggest inhibiting the CXCL5-CXCR2...
BC Innovations | Jul 21, 2011
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Chemokine CXC motif ligand 5 (CXCL5; ENA78) A study in humans and in rats suggests antagonizing CXCL5 could treat sunburn-associated pain. In biopsies of...
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