18:07 , May 15, 2018 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Arthritis In vitro and mouse studies identified a chemokine-targeting single-chain variable fragment (scFv)-based fusion protein that could help treat arthritis. Screening of a scFv library for binding to various human and mouse chemokines, engineering of...
00:08 , Dec 9, 2017 |  BC Extra  |  Preclinical News

A faster method for harvesting HSCs for transplantation

Researchers report a new two-drug regimen could speed up harvesting of hematopoietic stem cells for transplantation and yield a population of cells that engraft more efficiently than those produced by standard regimens. In a paper published...
07:00 , Jun 19, 2014 |  BC Innovations  |  Targets & Mechanisms

CXCR2 antibodies for antitumor immunity

A National Cancer Institute team has found a new chemokine-regulated pathway of tumor immune evasion that could account for some patients' resistance to checkpoint inhibitor-based therapies.1 By blocking CXC chemokine receptor 2, the team prevented...
07:00 , Aug 9, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Chemokine CXC motif ligand 1 (CXCL1; GRO; MGSA); CXCL2 (MIP2); CXC chemokine receptor 2 (CXCR2; IL8RB)...
07:00 , Aug 9, 2012 |  BC Innovations  |  Targets & Mechanisms

CXCR2 antagonists in breast cancer

A team at the Memorial Sloan-Kettering Cancer Center has shown that CXC chemokine receptor 2 antagonists sensitized tumors to chemotherapy in mouse models of metastatic breast cancer.1 The team is working on additional preclinical studies...
08:00 , Jan 13, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Imaging

This week in techniques Approach Summary Licensing status Publication and contact information Imaging Imaging of stabilized lung fragments without disrupting blood flow or ventilation A lung imaging technique...
07:00 , Jun 18, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease Influenza Interferon...
07:00 , Oct 2, 2008 |  BC Innovations  |  Targets & Mechanisms

Autoimmunity Gets Mincle and Dimed

Researchers at the RIKEN Research Center for Allergy and Immunology have identified MINCLE as a receptor that triggers neutrophil recruitment and secretion of proinflammatory cytokines in response to necrotic cells derived from injured tissue.1 Companies...
07:00 , Apr 3, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker /pathway Summary Licensing status Publication and contact information Autoimmune disease ...