BioCentury | Oct 2, 2020
Distillery Therapeutics

Targeting CXCL1 signaling for HSV-1 encephalitis

...CXCR2 antagonist navarixin in combination with Keytruda pembrolizumab in Phase II testing to treat solid tumors.TARGET/MARKER/PATHWAY: Chemokine CXC motif...
...15, 2020doi:10.1016/j.celrep.2020.108150CONTACT: Andrew D. Luster, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.email: aluster@mgh.harvard.edu Claire Quang Massachusetts General Hospital Harvard Medical School Chemokine CXC motif...
BioCentury | Aug 27, 2020
Distillery Therapeutics

Targeting CXCR3, CXCL9 for osteoporosis

...CXCR3 inhibitors in human pre-osteoclast cell cultures and mouse models.TARGET/MARKER/PATHWAY: CXC chemokine receptor 3 (CXCR3); chemokine CXC motif...
...online July 27, 2020doi:10.1073/pnas.2006093117CONTACT: Christoph Winkler, National University of Singapore, Singaporeemail: dbswcw@nus.edu.sg. Claire Quang National University of Singapore Chemokine CXC motif...
BioCentury | Apr 21, 2020
Product Development

Trio of tactics to target COVID-19 hyperinflammation

...CDK2 - Cyclin dependent kinase 2 CDK9 - Cyclin dependent kinase 9 CXCL10 (IP-10) - Chemokine CXC motif...
...of Edinburgh Novimmune S.A. Complement 5 (C5) Cyclin dependent kinase 2 (CDK2) Cyclin dependent kinase 9 (CDK9) Toll-like receptor 4 (TLR4) Chemokine CXC motif...
BioCentury | Jan 24, 2020
Preclinical News

Jan. 23 Preclinical Quick Takes: Metastasis-associated cancer-associated fibroblast populations; plus NIH-TeneoBio and Basilea

...Tumor necrosis factor receptor superfamily member 17; CD29 - Integrin β(1); CXCL12 (SDF-1) - Chemokine CXC motif...
BioCentury | Jan 18, 2020
Financial News

I-Mab dips in NASDAQ debut, first in years for an innovative Chinese biopharma

...receptor 5A; CXCL13 - Chemokine CXC motif ligand 13 Hongjiang Li, Staff Writer I-Mab Biopharma Complement receptor 5A (C5AR1) (C5AR) (CD88) Chemokine CXC motif...
BioCentury | Dec 13, 2019
Preclinical News

Dec. 12 Preclinical Quick Takes: POC for Aptose blood cancer candidate, plus Penn-Acorn AI, Neurimmune-Biogen and Syndax

...Btk - Bruton’s tyrosine kinase; C9orf72 - Chromosome 9 open reading frame 72; CXCL13 - Chemokine CXC motif...
...Inc. University of Pennsylvania Medidata Solutions Inc. Aptose Biosciences Inc. University of Texas MD Anderson Cancer Center Bruton's tyrosine kinase (Btk) Chemokine CXC motif...
BioCentury | Sep 13, 2019
Distillery Therapeutics

CXCL10-CXCR3 axis inhibition to block brain metastasis from melanoma

...human mAb against CXCL10, is in Phase II testing to treat ulcerative colitis (UC). TARGET/MARKER/PATHWAY: Chemokine CXC motif...
...2019 doi:10.1016/j.celrep.2019.07.033 CONTACT: Neta Erez, Tel Aviv University, Tel Aviv, Israel email: netaerez@tauex.tau.ac.il Claire Quang Tel Aviv University Chemokine CXC motif...
BioCentury | Aug 22, 2019
Distillery Techniques

Delivering mAbs to CNS metastases using polymer-based nanoparticles

...nanoparticles formed by cross-linking methacryloyloxyethyl phosphorylcholine monomers to glycerol dimethacrylate, then conjugating the nanocapsules to chemokine CXC motif...
BioCentury | Jul 11, 2019
Targets & Mechanisms

The tumor stroma rises as the newest source of immuno-oncology targets

...necrosis factor receptor superfamily member 9 CXCL9 (MIG) - Chemokine CXC motif ligand 9 CXCL10 (IP-10) - Chemokine CXC motif...
BioCentury | Feb 1, 2019
Tools & Techniques

TMB needs company

...motif ligand 5; CD8A (p32; CD8); CMKLR1 (ChemR23) - Chemokine-like receptor 1; CXCL9 (MIG) - Chemokine CXC motif...
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