16:18 , Mar 2, 2018 |  BC Week In Review  |  Clinical News

Kancera's KAND567 well tolerated in Phase I

Kancera AB (SSE:KAN) reported data from a Phase I trial in 82 healthy volunteers showing that lymphoma, inflammation and cardiovascular disease candidate KAND567 (AZD8797) was well tolerated. The double-blind, placebo-controlled trial evaluated single doses of...
15:44 , Mar 29, 2017 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Obesity Mouse studies suggest CX3CL1 could help treat obesity. In a mouse model of diet-induced obesity, female mice had high levels of CX3CL1 in the hypothalamus and gained less weight than male mice, which...
23:51 , Feb 28, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Cytomegalovirus (CMV) Studies in cells suggest a bacterial toxin-based inhibitor of US28 could help treat latent CMV infection. In a human monocyte cell line expressing US28, a fusion protein consisting of the US28-binding chemokine...
07:00 , Oct 13, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Chemokine CX3C motif receptor 1 (CX3CR1)

Inflammation INDICATION: Shock / trauma Mouse studies suggest inhibiting CX3CR1 could help treat the chronic phase of traumatic brain injury (TBI). In a mouse model of chronic-phase TBI, CX3CR1 knockout decreased lesion size, hippocampal damage...
07:00 , Apr 25, 2016 |  BC Week In Review  |  Clinical News

Anti-CX3CR1 Nanobody: Phase I started

Boehringer began a Phase I trial to evaluate single ascending doses of IV anti-CX3CR1 Nanobody. The start triggered a EUR8 million ($9 million) milestone payment to Ablynx from Boehringer under a 2007 deal to use...
07:00 , Jul 23, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: CMV CC chemokine receptor (US28)

Infectious disease INDICATION: Cytomegalovirus (CMV) In vitro and mouse studies identified a bacterial toxin-based inhibitor of US28 that could help treat human cytomegalovirus (HCMV) infection. Chemical synthesis and in vitro testing of chemokine-toxin fusion proteins...
07:00 , May 21, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Interleukin-1 (IL-1) β; IL-1 receptor; purinergic receptor P2X ligand-gated ion channel 7 (P2RX7; P2X7)

Ophthalmic disease INDICATION: Age-related macular degeneration (AMD) In vitro and mouse studies suggest inhibiting P2RX7 or IL-1β/IL-1 receptor signaling could help treat AMD. Subretinal accumulation of chemokine CX3C motif receptor 1 ( CX3CR1 )-deficient mononuclear...
07:00 , May 22, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Chemokine CX3C motif receptor 1 (CX3CR1); chemokine CX3C motif ligand 1 (CX3CL1; fractalkine) In vitro and mouse studies suggest antagonizing CX3CR1 or preventing cleavage...
07:00 , Oct 24, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

This week in techniques Approach Summary Licensing status Publication and contact information Disease models Chemokine CX3C motif receptor 1 (CX3CR1) promoter-dependent gene expression in microglia A microglia-specific expression system could help study the role of...
07:00 , Oct 3, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Renal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Renal disease Glomerulonephritis Chemokine CX3C motif receptor 1 (CX3CR1) Mouse studies suggest inhibiting CX3CR1 could help treat glomerulonephritis. In a mouse model of crescentic glomerulonephritis, Cx3cr1...