02:24 , Mar 29, 2019 |  BC Innovations  |  Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

New and emerging targets at AACR 2019 show cancer researchers are gaining granularity on how to manipulate the tumor microenvironment, a top priority goal for the field. The targets point to emerging strategies for modulating...
05:02 , Nov 30, 2018 |  BC Innovations  |  Targets & Mechanisms

Souped-up CARs at ASH 2018

Rather than searching for new antigens, makers of the latest generation of CAR therapies are focusing on the CARs themselves by designing more sophisticated methods of targeting multiple antigens, controlling cytotoxicity and enhancing tumor-homing. BioCentury’s...
21:30 , Nov 16, 2017 |  BC Innovations  |  Tools & Techniques

Internal logic

Instead of designing T cells to fight cancer, an MIT group is using synthetic biology to directly manipulate the tumor cells and make them more immunogenic. The big advantage, says the team, is that the...
20:45 , Oct 31, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Cancer; ovarian cancer; solid tumors Mouse studies suggest a self-regulating synthetic gene circuit that induces tumor-specific expression of immunostimulatory proteins could help treat ovarian cancer and other solid tumor types. The synthetic circuits were...
07:00 , Sep 1, 2016 |  BC Innovations  |  Translation in Brief

Bacteria with a pulse

A UCSD-led team has programmed bacteria to deliver controlled pulses of therapeutic proteins in vivo, and is spinning out Gencirq LLC to commercialize the technology. In a study in Nature , the orally delivered bacteria...
07:00 , Aug 18, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Bacteria engineered to generate pulses of therapeutic proteins in vivo

Drug platforms TECHNOLOGY: Expression systems A bacterial system that generates pulses of therapeutic proteins in vivo for long-term delivery could help treat cancer and other diseases. The system consisted of an attenuated strain of Salmonella...
07:00 , Jul 10, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Hematology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Bone marrow transplant (BMT) Chemokine CC motif ligand 21 (CCL21); CCL25 Mouse studies suggest pretreatment of bone marrow cells with CCL21 and CCL25 could enhance...
07:00 , Jun 19, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Markers

Approach Summary Licensing status Publication and contact information Markers Loss of olfaction as an early symptom of cerebral malaria Mouse studies suggest loss of olfaction could be an early indicator of cerebral malaria infection. In...
08:00 , Mar 5, 2001 |  BioCentury  |  Tools & Techniques

Vertex: Stopping metastasis

The human chemokine receptor CXCR4 has been known since the mid-1990s as a co-factor for the entry of HIV into cells. New findings reported last week by DNAX Research Institute implicate CXCR4 and another chemokine...