BioCentury | Jun 20, 2020
Translation in Brief

CAR Ts against senescent cells; plus NIH program for ALS, sex-dependent COVID-19 immune responses and more

...Targets IL-15 - Interleukin-15 PLAUR (uPAR) (suPAR) - Plasminogen activator urokinase receptor RANTES (CCL5) - Chemokine CC motif...
...Amsterdam BridgeBio Pharma Inc. Johns Hopkins University Plasminogen activator urokinase receptor (PLAUR) (uPAR) (suPAR) SARS-CoV-2 spike protein (SARS-CoV-2 S) Interleukin-15 (IL-15) Chemokine CC motif...
BioCentury | Nov 14, 2019
Company News

Nov. 13 Company Quick Takes: FDA panel rebuffs Jardiance; plus Nucala, Cellular Biomedicine, BeiGene, Autolus and Noile-Immune

...engineering T cells including CAR Ts to secrete IL-7 and CCL19. Targets: CCL19 (ELC) - Chemokine CC motif...
BioCentury | Oct 8, 2019

Novel targets induce cardiomyocyte regeneration

...15%, and reduced fibrosis and ventricular dilation (see "Stimulating Heart Regeneration Following Injury" ). TARGET/MARKER/PATHWAY: Chemokine CC motif...
...University of Texas shouthwestern Medical Center, Dallas, Texas e-mail: eric.olson@utsouthwestern.edu Inhua Muijrers-Chen University of Texas Southwestern Medical Center Chemokine CC motif...
BioCentury | Oct 3, 2019
Targets & Mechanisms

Stimulating heart regeneration following injury

...reducing fibroblast proliferation to inhibit scarring; and enhancing angiogenesis and macrophage infiltration. Targets: CCL24 - chemokine CC motif...
...insulin-like growth factor 2 mRNA binding protein 3 Inhua Muijrers-Chen, Associate Editor University of Texas Southwestern Medical Center Chemokine CC motif...
BioCentury | Aug 27, 2019
Company News

Aug. 27 Company Quick Takes: GSK licenses Ionis HBV program; plus Adaptimmune-Noile, Purdue, Presage-BMS, Kyowa, Alexion, Viela, Kintai, OncoNano

...series A financing to bring the round to $35.4 million raised. Targets: CCL19 (ELC) - Chemokine CC motif...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...AXL (UFO) - AXL receptor tyrosine kinase CCL19 (ELC) - Chemokine CC motif ligand 19 CCL21 - Chemokine CC motif...
...Tuzman, Associate Editor Arcus Biosciences Inc. Celldex Therapeutics Inc. Merrimack Pharmaceuticals Inc. Meryx Inc. MiNA Therapeutics Ltd. c-Mer proto-oncogene tyrosine kinase (MERTK) Chemokine CC motif...
BioCentury | Feb 1, 2019
Tools & Techniques

TMB needs company

...T cells ( teal ), which suppress activated T cells. B7-H3 (CD276); CCL5 (RANTES) - Chemokine CC motif...
BioCentury | Jan 26, 2019
Product Development

Raising the BD bar

...orally-administered small molecule CC chemokine receptor 3 (CCR3; CD193) inhibitor that blocks the action of chemokine CC motif...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Souped-up CARs at ASH 2018

...member 9 Cas9 - CRISPR-associated protein 9 CCL19 (ELC) - Chemokine CC motif ligand 19 CCL21 - Chemokine CC motif...
...family 12 member A (CLEC12A) (CLL1) CC chemokine receptor 7 (CCR7) (CD197) CD19 CD28 CD33 (SIGLEC3) Chemokine CC motif ligand 19 (CCL19) (ELC) Chemokine CC motif...
BioCentury | Nov 15, 2018
Translation in Brief

The bystander effect of Treg depletion

...infiltration of Tregs into the tumor by blocking the chemokine receptor’s interaction with its ligands chemokine CC motif...
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