BC Innovations | Aug 23, 2019
Targets & Mechanisms

New targets in osteoarthritis are about more than just pain

New biological insights and increased recognition from FDA are transforming osteoarthritis from a testing ground for new pain therapies into its own high-priority indication. At least two mechanisms with disease-modifying potential for osteoarthritis (OA) have...
BC Innovations | Jul 31, 2017
Distillery Therapeutics


INDICATION: Liver disease In vitro and mouse studies identified a triazoloquinolone-based CLK-1 inhibitor that could help treat acute liver injury (ALI). In silico screening of small compound libraries, chemical synthesis of analogs of the screening...
BC Innovations | Jun 9, 2016
Distillery Therapeutics

Therapeutics: Calmodulin; CDC-like kinase 1 (CLK-1); vascular endothelial growth factor receptor 3 (FLT4; VEGFR-3); K(lysine) acetyltransferase 5 (KAT5); acetyl

Infectious disease INDICATION: Chikungunya virus Cell culture and mouse studies identified inhibitors of calmodulin , CLK-1 , FLT4, KAT5 and other host factors that could help treat Chikungunya viral infection. Screening of an siRNA library targeting about...
BC Innovations | Feb 24, 2011
Distillery Therapeutics

Indication: Various

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Influenza virus; cancer CDC-like kinase 1 (CLK1); CLK4 An in vitro study identified a dual inhibitor of CLK1 and CLK4 that...
BC Week In Review | May 1, 2006
Clinical News

CHGN111: Phase I/II start

Chronogen will begin this week an open-label Canadian Phase I/II trial in 24 healthy volunteers. Chronogen Inc. , Montreal, Quebec   Product: CHGN111   Business: Dermatology   Molecular target: CLK-1   Description: Mitochondrial enzyme CLK-1 inhibitor...
BC Week In Review | Nov 25, 2002
Company News

Chronogen, McGill University deal

Chronogen exclusively licensed from the university proteins CLK-1 , CLK-2, and ISP-1, in addition to a series of targets for age-dependent diseases like cardiovascular disorders and cancer. The company said the proteins are associated in the...
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