19:45 , Nov 6, 2018 |  BC Innovations  |  Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cellular assays; gene profiling; tissue markers Gene profiling coupled with cell-based assays of patient samples could help predict drug responses in AML patients. In tumor samples from 363 patients, whole-exome sequencing plus genotyping of...
00:38 , Jan 27, 2018 |  BC Extra  |  Company News

FDA to review its pediatric exclusivity decision for Amgen's Sensipar

A federal judge ordered FDA to address whether its decision to grant pediatric exclusivity to Ortho Tri-Cyclen norgestimate/ethinyl estradiol from the Janssen Pharmaceuticals Inc. unit of Johnson & Johnson (NYSE:JNJ) is consistent with its decision...
18:36 , Jan 11, 2018 |  BC Innovations  |  Emerging Company Profile

Next, after T cells

PD-1 pioneer Lieping Chen is solving some of the unanswered questions from that breakthrough with his new company, NextCure Inc. The idea is to use myeloid cell factors to boost the effectiveness of other T...
02:27 , Jul 13, 2017 |  BC Week In Review  |  Clinical News

FDA approves Orencia for psoriatic arthritis

FDA approved Orencia abatacept from Bristol-Myers Squibb Co. (NYSE:BMY) to treat psoriatic arthritis. The product is a CTLA-4 (CD152)-Ig fusion protein available in both IV and subcutaneous formulations. It is already approved in the U.S....
18:29 , Jul 6, 2017 |  BC Week In Review  |  Clinical News

EMA's CHMP recommends Orencia in psoriatic arthritis

EMA’s CHMP recommended a label expansion for Orencia abatacept (ONO-4164IV) from Bristol-Myers Squibb Co. (NYSE:BMY) to include treatment of active psoriatic arthritis in adults for whom previous disease-modifying anti-rheumatic drug (DMARD) therapy, including methotrexate ,...
12:26 , Jun 22, 2017 |  BC Week In Review  |  Clinical News

Ono, BMS submit supplemental application in Japan for Orencia to treat JIA

Ono Pharmaceutical Co. Ltd. (Tokyo:4528) and Bristol-Myers Squibb Co. (NYSE:BMY) submitted a supplemental application in Japan for IV Orencia abatacept (ONO-4164IV) to treat active polyarticular juvenile idiopathic arthritis (JIA). The CTLA-4 (CD152)-Ig fusion protein is...
17:06 , Mar 15, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Chikungunya virus Mouse studies suggest Gilenya fingolimod, Orencia abatacept and Xeljanz tofacitinib could help treat Chikungunya infection. Testing of a total of 11 drugs in mouse models of Chikungunya infection by two independent groups...
00:37 , Feb 3, 2017 |  BC Week In Review  |  Clinical News

Subcutaneous Orencia: Ph III data

An open-label, international Phase III trial in 205 patients with active polyarticular JIA with an inadequate response or intolerance to ≥1 DMARD showed that once-weekly subcutaneous Orencia for 4 months led to a Cmin of...
19:13 , Jan 20, 2017 |  BC Week In Review  |  Clinical News

Subcutaneous Orencia: Ph III ASTRAEA data

The double-blind, international Phase III ASTRAEA trial in 424 patients with psoriatic arthritis who had a ≥2 cm target lesion of plaque psoriasis and inadequate response or intolerance to ≥1 non-biologic DMARD showed that once-weekly...
23:56 , Nov 2, 2016 |  BC Innovations  |  Distillery Therapeutics

Infectious disease; inflammation

INDICATION: Sepsis; inflammation Cell culture and mouse studies identified CD86 -derived peptide mimetics that could help treat inflammation association with bacterial sepsis. Chemical synthesis and testing in a bacterial antigen-treated human liver cell line of...