22:43 , Apr 10, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Tumor stromal levels of cytotoxic tumor lymphocytes and macrophages could help predict survival in melanoma. In primary tumor stroma samples from 104 melanoma patients with stage II or III tumors, low ratios...
21:49 , Jul 27, 2017 |  BC Innovations  |  Product R&D

Spheres of influence

AstraZeneca plc and Genentech Inc. have joined forces to test whether a liver spheroid system can improve upon the gold standard for preclinical prediction of hepatotoxicity. The goal is to raise the bar on preventing...
07:00 , Aug 20, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: CD68 (LAMP4)

Infectious disease INDICATION: Malaria In vitro and mouse studies suggest inhibiting CD68 could help treat malaria. Screening of a phage display peptide library for binding to Kupffer cells identified a cell-binding peptide that decreased Plasmodium...
07:00 , Mar 25, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Markers

Approach Summary Licensing status Publication and contact information Markers Tumor-associated macrophages as a biomarker for therapy responsiveness and patient survival in Hodgkin's lymphoma A study in patient samples suggests that tumor-associated macrophages could be useful...
07:00 , Sep 21, 2009 |  BC Week In Review  |  Clinical News

ADC4022: Phase II data

Data from 91 patients in a double-blind, U.K. and Polish Phase II trial showed that ADC4022 given in combination with inhaled budesonide significantly improved lung function as measured by difference between treatment groups in forced...