BioCentury | Jun 27, 2019
Product Development

Gene therapy’s next frontier lies beyond rare, monogenic diseases

...cascade, Hemera Biosciences Inc.’s Phase I AMD gene therapy HMR59 delivers a soluble form of CD59...
...Co-founder and CEO Adam Rogers. According to BCIQ, no other therapies targeting C9 or delivering CD59...
BioCentury | Feb 22, 2019
Emerging Company Profile

Gyroscope complements dry AMD

...Biosciences Inc. has HMR-101 in Phase I testing; the intravitreally injected product expresses a soluble CD59...
BioCentury | Jan 21, 2016
Distillery Therapeutics

Therapeutics: CD59; complement C5b-9 membrane attack complex (MAC)

...statins could help treat vascular damage associated with obstructive sleep apnea (OSA). Intracellular levels of CD59...
...In a human endothelial cell line incubated with normal human serum, hypoxic conditions increased cholesterol-dependent CD59...
...inflammation compared with normoxic conditions. In the serum-incubated cells under hypoxic conditions, Lipitor atorvastatin increased CD59...
BioCentury | Dec 10, 2015
Distillery Therapeutics

Therapeutics: V-set and immunoglobulin domain containing 4 (VSIG4); CD59; complement C5b-9 membrane attack complex (MAC)

...CD59 fusion protein could help treat traumatic brain injury (TBI). In vitro, dimers of the VSIG4-CD59...
...C3b) with a Kd of 0.55 µM. In a mouse model of TBI, a mouse VSIG4-CD59...
...version of the VSIG4-CD59 fusion protein. TARGET/MARKER/PATHWAY: V-set and immunoglobulin domain containing 4 (VSIG4) ; CD59...
BioCentury | Sep 11, 2014
Distillery Therapeutics

Indication: Hepatic disease

...Complement receptor 2 (CR2); CD59; complement C5b-9 membrane attack complex (MAC) Mouse studies suggest a CR2-CD59...
...surgery. In mouse models of hepatic ischemia/reperfusion injury or partial or massive hepatectomy, a mouse Cr2-Cd59...
...MAC without also blocking other components of the complement system. In these models, the mouse Cr2-Cd59...
BioCentury | Jul 28, 2014
Company News

Corgenix Medical Corp., Mellitus deal

...Corgenix will develop a research test kit to measure glycated CD59 for use in Mellitus’ in...
BioCentury | Oct 21, 2013
Emerging Company Profile

Hemera: Special sauce in AMD

...of the cascade, which directly damages cell membranes. The product delivers the gene encoding the CD59...
...developed a gene therapy that delivers the gene encoding a soluble recombinant form of human CD59...
BioCentury | Dec 8, 2011
Cover Story

Big MAC attack in osteoarthritis

...severe disease than wild-type models that received inactive controls. Models deficient in the MAC inhibitor Cd59...
BioCentury | Feb 14, 2011
Strategy

Alexion's expansions

...at least three other compounds: TT31, a CFH replacement for acute injury; TT33 , a CD59...
BioCentury | Jul 28, 2008
Company News

Arius, Roche deal

...is expected to start Phase I testing in 2009; AR003 (formerly AR36A36.11.1), a mAb against CD59...
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