BioCentury | Jan 25, 2020
Targets & Mechanisms

CAR T strategies for cracking the code in solid tumors

...PD-1) (PDCD1) (CD279) Programmed cell death 1 ligand 1 (PD-L1) (B7-H1) (CD274) CD70 (CD27L) Splice variant v6 of CD44...
BioCentury | Dec 1, 2018
Product Development

Cell therapy momentum at ASH

...728 Vita-Salute San Raffaele University / Novartis Institutes for BioMedical Research Splice variant v6 of CD44...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...chromatin reader BRD4, induces sustained BRD4 depletion and down-regulation of BRD4 target genes in the CD44-Notch...
BioCentury | Jun 14, 2018
Translation in Brief

There’s more to MIF

...interact with multiple receptors, including CXC chemokine receptor 2 (CXCR2; IL8RB), CXCR4 (NPY3R) and co-receptor CD44...
BioCentury | Jun 13, 2018
Distillery Techniques

Assays and screens

...of the captured cells for the bladder cancer markers CD20 and splice variant v6 of CD44...
...CONTACT: Ray P.S. Han, Peking University, Beijing, China email: ray-han@pku.edu.cn Hongjiang Li Peking University CD20 Splice variant v6 of CD44...
BioCentury | Feb 13, 2018
Distillery Techniques

Assays and screens; disease models

...treated with Tarceva did not develop Tarceva resistance. Also in the Tarceva-treated GBM hydrogel culture, CD44-targeting...
...Seidlits, University of California Los Angeles, Los Angeles, Calif. email: seidlits@ucla.edu Hongjiang Li Tarceva University of California Los Angeles CD44 Epidermal...
BioCentury | Dec 13, 2017
Distillery Therapeutics

Cancer

...migration, invasiveness, the epithelial-to-mesenchymal transition and expression of the cancer stem cell markers CD24 and CD44...
...Dec. 11, 2017 doi:10.1083/jcb.201705031 CONTACT: Ira Mellman, Genentech, South San Francisco, Calif. email: mellman.ira@gene.com Allison Johnson Genentech Inc. Roche CD24 CD44 Lysine...
BioCentury | Dec 11, 2017
Preclinical News

Histone modifier is implicated in epithelial-mesenchymal transition

...KMT5C expression. KMT5C knockdown also decreased expression of the cancer stem cell markers CD24 and CD44...
...disclose whether the company is developing KMT5C inhibitors or other modulators of the KMT5C pathway. Allison Johnson Roche CD24 CD44 Forkhead...
BioCentury | Nov 2, 2017
Product R&D

Sweet specificity

...auristatin E (MMAE). Because sTn decorates multiple proteins in cancer, including MUC1 , MUC16 and CD44...
...GmbH European Organization for Research and Treatment of Cancer National Cancer Institute Siamab Therapeutics Inc. University of California San Diego CD44 Mucin...
BioCentury | Nov 2, 2016
Clinical News

AMC303: Ph I/Ib started

...amcure GmbH , Eggenstein-Leopoldshafen, Germany Product: AMC303 Business: Cancer Molecular target: Splice variant v6 of CD44...
...II dose and pharmacokinetics Status: Phase I/Ib started Milestone: NA Julian Zhu AMC303 amcure GmbH Splice variant v6 of CD44...
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