BioCentury | Jan 31, 2018
Distillery Techniques

Drug delivery

...TECHNOLOGY: Targeting domains Antibodies targeting CDCP1 and other extracellular antigens up-regulated by Ras could be used...
...KRAS) G12V mutation or wild-type KRAS identified seven single-pass transmembrane receptors -- including CUB domain containing protein 1 (CDCP1; CD318...
...human KRAS-mutant pancreatic cancer cell line, an antibody-drug conjugate (ADC) consisting of IgG against human CDCP1...
BioCentury | Jan 25, 2018
Preclinical News

Targeting RAS via surface proteins

...researchers then evaluated the ability of an antibody against one of the targets, CUB domain containing protein 1 (CDCP1; CD318...
...than 60%. The authors also showed a bispecific T cell engager (BiTE) engineered with the CDCP1-targeted...
...found a CDCP1 antigen-binding fragment showed increased tumor staining compared with a control fragment, suggesting CDCP1...
BioCentury | Aug 29, 2017
Distillery Therapeutics

Autoimmune disease

...INDICATION: Multiple sclerosis (MS) Mouse studies suggest inhibiting CDCP1 could help treat MS. In the experimental...
...help treat MS. In the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, knockout of CDCP1...
...compared with normal CDCP1 expression. Next steps include developing an anti-CDCP1 mAb. TARGET/MARKER/PATHWAY: CUB domain containing protein 1 (CDCP1; CD318...
BioCentury | Aug 9, 2017
Distillery Therapeutics

Cancer

...CDCP1 could help treat metastatic triple-negative breast cancer (TNBC). In three human TNBC cell lines, CDCP1...
...CDCP1 expression. In two of the cell lines, a lentiviral vector encoding a dominant negative CDCP1...
...Next steps could identifying and testing CDCP1 inhibitors in models of TNBC. TARGET/MARKER/PATHWAY: CUB domain containing protein 1 (CDCP1; CD318...
BioCentury | Aug 2, 2017
Preclinical News

CDCP1 identified as potential autoimmune target

...in Proceedings of the National Academy of Sciences , researchers linked CUB domain containing protein 1 ( CDCP1 ; CD318...
...Cleveland Clinic and the University of Michigan . In epithelial cells, the team first identified CDCP1...
...BCIQ database, there are currently no candidates in development targeting CDCP1. Mary Romeo Cleveland Clinic University of Michigan CD6 CUB domain containing protein 1 (CDCP1...
BioCentury | May 28, 2015
Distillery Therapeutics

Therapeutics: CUB domain containing protein 1 (CDCP1); epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2; neu)

...and low survival. In HER2-positive breast cancer cell lines, CDCP1 activated HER2 and formed a CDCP1-HER2...
...normal CDCP1 expression. In mouse xenograft models of HER2-positive breast cancer, Herceptin and shRNA targeting CDCP1...
...steps include generating transgenic CDCP1 knock-in mouse models of breast and prostate cancer. TARGET/MARKER/PATHWAY: CUB domain containing protein 1 (CDCP1...
BioCentury | Aug 28, 2014
Distillery Therapeutics

Indication: Cancer

...Lung cancer ADAM9; CUB domain containing protein 1 (CDCP1) Studies in patient samples and mice suggest inhibiting ADAM9 or CDCP1...
...lung cancer. In mice, injection of lung cancer cells with shRNA knockdown of ADAM9 or CDCP1...
...and CDCP1 levels correlated with poor prognosis. Ongoing studies include identifying compounds that block the ADAM9-CDCP1...
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