03:20 , Feb 16, 2019 |  BioCentury  |  Product Development

ADCs’ inflection point

Industry is writing a new rule book for antibody-drug conjugates that could take the modality beyond the one-size-fits-all approach that has limited its success. By 2Q20, late-stage data from at least four ADCs testing new...
19:50 , Feb 15, 2019 |  BC Week In Review  |  Clinical News

Seattle Genetics gets $30M milestone for EU approval of Adcetris in first-line Hodgkin lymphoma

Seattle Genetics Inc. (NASDAQ:SGEN) will receive a $30 million milestone payment from Takeda Pharmaceutical Co. Ltd. (Tokyo:4502) triggered by the European Commission's decision to expand the label of Adcetris brentuximab vedotin to include previously untreated...
21:50 , Feb 8, 2019 |  BC Extra  |  Company News

Seattle Genetics down on light 2019 Adcetris sales guidance

Seattle Genetics Inc. (NASDAQ:SGEN) fell $8.73 (12%) to $65.02 Friday after announcing late Thursday 2019 guidance for Adcetris brentuximab vedotin sales below the consensus estimate. The move represents a market cap loss of almost $1.4...
20:43 , Dec 21, 2018 |  BC Week In Review  |  Clinical News

CHMP backs Besremi for polycythemia vera, two Shionogi drugs

EMA's CHMP recommended a basket of approvals and label extensions on Dec. 14, including Orphan Drug Besremi ropeginterferon alfa-2b to treat polycythemia vera and a pair of treatments from Shionogi & Co. Ltd. (Tokyo:4507). The...
23:22 , Dec 14, 2018 |  BC Extra  |  Company News

CHMP backs Besremi for polycythemia vera, two Shionogi drugs

EMA's CHMP recommended a basket of approvals and label extensions on Friday, including Orphan Drug Besremi ropeginterferon alfa-2b to treat polycythemia vera and a pair of treatments from Shionogi & Co. Ltd. (Tokyo:4507). The agency...
21:06 , Dec 14, 2018 |  BC Week In Review  |  Clinical News

Adcetris improves PFS by 27.4 months in first-line PTCL

Seattle Genetics Inc. (NASDAQ:SGEN) and Takeda Pharmaceutical Co. Ltd. (Tokyo:4502) reported detailed data from the Phase III ECHELON-2 trial to treat previously untreated CD30-expressing peripheral T cell lymphoma (PTCL) showing that Adcetris brentuximab vedotin plus...
03:50 , Dec 1, 2018 |  BioCentury  |  Product Development

Cell therapy momentum at ASH

This year’s American Society of Hematology (ASH) meeting will showcase a surge in clinical CAR T cell presentations. But gene therapies are not following the same trajectory, despite both modalities being fresh off their first...
04:32 , Nov 30, 2018 |  BC Week In Review  |  Clinical News

Adcetris gets speedy label expansion under FDA real-time pilot

FDA approved a label expansion for Adcetris brentuximab vedotin less than two weeks after Seattle Genetics Inc. (NASDAQ:SGEN) submitted the sBLA. The agency said Adcetris is the first U.S.-approved treatment for newly diagnosed peripheral T-cell...
00:10 , Nov 17, 2018 |  BC Extra  |  Company News

Adcetris gets speedy label expansion under FDA real-time pilot

FDA approved a label expansion for Adcetris brentuximab vedotin less than two weeks after Seattle Genetics Inc. (NASDAQ:SGEN) submitted the sBLA. The agency said Adcetris is the first U.S.-approved treatment for newly diagnosed peripheral T-cell...
22:08 , Oct 26, 2018 |  BC Extra  |  Company News

Seattle Genetics sags as Adcetris sales miss target

Seattle Genetics Inc. (NASDAQ:SGEN) lost $10.05 (15%) to $55.30 on Friday after 3Q18 sales of Adcetris brentuximab vedotin fell short of expectations, and the cancer company predicted relatively flat sales in 4Q18. Adcetris delivered $127...