BioCentury | Oct 9, 2020
Translation in Brief

Philogen immunocytokine for glioma; plus Nordic's radiotherapy, Beth Israel Deaconness, Molecular Partners and Alpine

...modelling acute myeloid leukemia that had been given human peripheral blood mononuclear cells. The dual, inducible ICOS/CD28...
...South Carolina Alpine Immune Sciences Inc. Nordic Nanovector ASA Molecular Partners AG Inducible T cell co-stimulator ligand (ICOSLG) (B7-H2) (B7RP1) CD28 Inducible...
BioCentury | Sep 5, 2020
Translation in Brief

Matt Disney’s microRNA-targeting angiogenesis compound; Arrakis’ platform to find compounds’ RNA targets; dual target CAR Ts for HIV and more

...cell that encodes two CARs, one with CD28...
...plc Cancer Research UK Vascular endothelial growth factor A (VEGF-A) CD4 CD28 Tumor...
BioCentury | Jul 17, 2020
Emerging Company Profile

Acepodia: linking antitumor antibodies to immune cells

...strong NK cell activation receptors,” said Hsiao, adding that CAR constructs commonly incorporate CD3 and CD28...
...applications and off-the-shelf NK cell technology Targets CD3 CD16 (FCGR3) - Fc γ receptor III CD28...
...2 PD-L1 (B7-H1; CD274) - Programmed cell death 1 ligand 1 Hongjiang Li, Staff Writer ACE1702 (ACE-NK-HER2) Acepodia Inc. CD3 CD28 Fc...
BioCentury | Jul 10, 2020
Product Development

Atox looks towards 3Q20 NDA submission for necrotizing infection candidate following Phase III readout

...ability to combat the infection. Reltecimod is a peptide antagonist of the T cell costimulator CD28...
...for sepsis-associated acute kidney injury due to slow patient enrollment. Sandi Wong, Assistant Editor reltecimod (AB103) Atox Bio Ltd. CD28 necrotizing...
BioCentury | Jun 27, 2020
Translation in Brief

Regeneron enhances checkpoint therapy with CD28 bispecifics; plus NIH funds Alzheimer’s brain mapping, Genentech and more

...Regeneron combines CD28 bispecifics with PD-1 mAb In its latest paper covering anti-CD28 bispecific antibodies, Regeneron...
...Translational Medicine that the bispecifics could boost anti-PD-1 efficacy. Bispecifics against CD28 and PSMA, or CD28...
...and skin cancer; the combination also induced antitumor immunity. In January, the company showed that CD28...
BioCentury | Jun 19, 2020
Deals

In second innovative deal this month, AbbVie gains option to Alpine’s ‘first-in-class’ lupus program

...receive an exclusive, worldwide option to license ALPN-101, an Fc fusion protein dual antagonist of CD28...
...BioCentury that ALPN-101’s dual CD28/ICOS antagonism is intended to block two populations of T cells. CD28...
...Ig fusion protein that blocks the costimulatory ligands CD80 and CD86, preventing their interaction with CD28...
BioCentury | Jan 17, 2020
Preclinical News

Jan 16 Preclinical Quick Takes: Deerfield's Orchard partners with Yeda; Acuitas-Penn flu vaccine in newborns; plus Regeneron, Genentech-Gladstone and Banyan

...In mouse models of prostate and ovarian cancer, costimulatory bispecifics against CD28 and PSMA, or CD28...
...of Science University of Pennsylvania Regeneron Pharmaceuticals Inc. Genentech Inc. Gladstone Institutes Banyan Biomarkers Inc. Influenza A virus hemagglutinin (Influenza A HA) CD28 Prostate-specific...
BioCentury | Nov 23, 2019
Product Development

Sanofi adds in home-grown trispecific antibody technology to grow oncology franchise

...targets CD38 on cancer cells and stimulates T cell proliferation through activation of CD3 and CD28...
...arms, with the monovalent CD38 targeting domain on one arm, and the monovalent CD3 and CD28...
...is a validated target for MM, and MM cells also express CD28, which suggests the CD28-targeting...
BioCentury | Aug 8, 2019
Translation in Brief

Lab mice with ‘wild’ microbiomes better reflect clinical data

...human and preclinical data, causing ineffective translation to the clinic. One incongruent example is an anti-CD28...
BioCentury | Aug 8, 2019
Distillery Techniques

Mice with wild microbiomes predict clinical results

...to those of wild than conventional lab mice. Wildlings treated with an agonist mAb targeting CD28...
...levels of anti-inflammatory cytokine IL-10 -- replicating results observed in a Phase I trial of CD28...
Items per page:
1 - 10 of 191