BioCentury | Jul 11, 2018
Translation in Brief

Poisoning the stromal chalice

A study published in the Journal of Clinical Investigation suggests antibody-drug conjugates targeting the tumor stroma could treat cancers by co-opting a stromal mechanism to feed cytotoxic drugs to the surrounding tumor cells. Tumor-associated stroma,...
BioCentury | Jun 13, 2018
Distillery Therapeutics

Cancer

INDICATION: Solid tumors; pancreatic cancer; colorectal cancer; breast cancer; lung cancer; ovarian cancer Patient sample and mouse studies suggest anti-ANTXR1 antibody-drug conjugates (ADCs) could help treat solid tumors. In tissue samples from esophageal, kidney, uterine,...
BioCentury | Dec 5, 2017
Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest chimeric antigen receptor (CAR) T cells targeting ANTXR1 could help treat triple-negative breast cancer (TNBC). In patient samples, levels of ANTXR1 were higher in...
BioCentury | Nov 2, 2016
Distillery Techniques

Other

...conformations. When applied to the β-lactamase CD248 endosialin (TEM1) and 14 variants, the model identified several TEM1...
...against cefotaxime. Next steps includes using results from the model to design non-covalent inhibitors of TEM1...
...of Medicine, St Louis, Mo. email: bowman@biochem.wustl.edu Hongjiang Li Washington University School of Medicine in St. Louis CD248 endosialin (TEM1...
BioCentury | Jul 9, 2015
Distillery Therapeutics

Therapeutics: Ras homolog enriched in striatum (RHES; RASD2; TEM2)

Neurology INDICATION: Huntington's disease (HD) Mouse studies suggest inhibiting RHES in the brain could help treat HD. In a transgenic mouse model of HD expressing mutant huntingtin (HTT) , systemic homozygous and heterozygous knockout of RHES...
BioCentury | Jan 22, 2015
Distillery Therapeutics

Therapeutics: Mammalian target of rapamycin complex 1 (mTORC1); RASD family member 2 (RASD2; Rhes; TEM2)

Neurology INDICATION: Huntington's disease (HD) Studies in patient samples and mice suggest increasing mTORC1 signaling could help treat HD. In striatal tissues samples from HD patients and a mouse model of HD, mTORC1 activity was...
BioCentury | Apr 24, 2014
Distillery Therapeutics

Indication: Cancer

...plasmid encoding a TEM1-tetanus toxoid (TT) fusion peptide could be used as a cancer vaccine. TEM1...
...tumors. In multiple mouse xenograft models of human cancer, vaccination with a DNA plasmid encoding Tem1-TT...
...resulted in decreased tumor angiogenesis and growth compared with vaccination using a DNA plasmid encoding Tem1...
BioCentury | Apr 17, 2014
Distillery Techniques

Technology: Assays & screens

Approach Summary Licensing status Publication and contact information Assays & screens Tumor endothelial marker (TEM)-expressing circulating endothelial cells (CECs) as a blood-based marker to detect tumors and monitor response to antiangiogenic therapy Studies in human...
BioCentury | Oct 14, 2013
Clinical News

MORAb-004: Phase I started

...Japan Product: MORAb-004 Business: Cancer Molecular target: CD248 endosialin (TEM1) Description: Humanized IgG mAb against CD248 endosialin (TEM1...
BioCentury | Aug 13, 2012
Clinical News

MORAb-004: Phase II started

...Japan Product: MORAb-004 Business: Cancer Molecular target: CD248 endosialin (TEM1) Description: Humanized IgG mAb against CD248 endosialin (TEM1...
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