BC Extra | Dec 9, 2019
Company News

Novartis downsizing internal efforts on CAR T in solid tumors

Novartis is pivoting away from internal development of CAR Ts in solid tumors, it said Thursday at its R&D day. The company is, however, pressing forward with the modality via partnerships, and plans to use...
BC Innovations | Aug 15, 2019
Distillery Techniques

Mutation combination as endometrial cancer biomarker

TECHNIQUES CATEGORY: Biomarkers TECHNOLOGY: Gene profiling; tissue markers; SNPs Michigan State University and Van Andel Institute researchers have linked a combination of two mutations -- a loss-of-function mutation in tumor suppressor ARID1A plus an activating...
BC Extra | Aug 9, 2019
Preclinical News

Aug. 8 Preclinical Quick Takes: Mayo Clinic assay for residual disease; plus camouflage for bacterial agents, Elicio's KRAS vaccine and more

Mayo Clinic liquid biopsy identifies breast cancer residual disease  A Mayo Clinic team reported in a Science Translational Medicine article that a personalized multiplex sequencing approach called TARDIS (targeted digital sequencing) could accurately distinguish pathological...
BC Extra | Jul 2, 2019
Preclinical News

July 2 Preclinical Quick Takes: Semma plans 2020 clinical trials of stem cell-derived islet products and more

Semma to bring stem cell-derived islet therapies for diabetes to clinic in 2020  Semma Therapeutics Inc. (Cambridge, Mass.) plans to start Phase I testing in early 2020 of its stem cell-derived islets combined with immunosuppression...
BC Extra | Jun 28, 2019
Preclinical News

June 28 Preclinical Quick Takes: BioNTech targets pancreatitis; plus new targets for HIV and more

Anti-glycan mAb licensed by BioNTech could prevent pancreatitis  A Science study from Cold Spring Harbor Laboratory suggests the glycan CA19.9 (sialyl Lewis A), long known as a biomarker of pancreatic disease, actively drives the progression...
BC Extra | Jun 4, 2019
Tools & Techniques

OHSU's Mitalipov proposes path forward for germline gene editing

Germline gene editing pioneer Shoukhrat Mitalipov has weighed in on therapeutic use of the technology, writing in a Nature Medicine perspective that it should only be applied when it can convert a mutated gene to...
BC Extra | Jun 3, 2019
Preclinical News

June 3 Preclinical Quick Takes: 'CRISPR baby' gene mutation increases mortality; Axial's microbiome for autism

CCR5 mutation linked to increased death rate  Using genomic and health data from over 400,000 individuals in the UK Biobank, University of California Berkeley researchers found that homozygous Δ32 mutations in CC chemokine receptor 5...
BC Extra | May 14, 2019
Company News

Management tracks: DBV, Beam, Aeon Biopharma

DBV Technologies S.A. (Euronext:DBV; NASDAQ:DBVT) said Deputy CEO and Principal Financial Officer David Schilansky will leave the company in August to pursue other opportunities. The allergy company is searching for a new CFO but will...
BC Innovations | Apr 25, 2019
Translation in Brief

Risking CRISPR correction before birth

A team from CHOP and UPenn has published its second study showing CRISPR-based gene editing can treat deadly diseases in the womb but has yet to address the safety repercussions for the mother and fetus....
BC Extra | Apr 12, 2019
Company News

Gilead, Novo team up to combine NASH compounds

A day after Gilead presented Phase II data at EASL for its cilofexor plus firsocostat combination to treat non-alcoholic steatohepatitis, the company partnered with Novo Nordisk to test the duo in combination with semaglutide in...
Items per page:
1 - 10 of 406