BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...last year, presented by three companies and five academic groups. The prominence of MERTK and CCL21...
...targets that shape the differentiation and recruitment of immune cells in the tumor microenvironment. Chemokine CCL21...
...AXL receptor tyrosine kinase CCL19 (ELC) - Chemokine CC motif ligand 19 CCL21 - Chemokine CC motif ligand 21...
BioCentury | Nov 30, 2018
Targets & Mechanisms

Souped-up CARs at ASH 2018

...an allogeneic NK CAR cell line that expresses CCR7. Because the receptor’s ligands, CCL19 and CCL21...
...Cas9 - CRISPR-associated protein 9 CCL19 (ELC) - Chemokine CC motif ligand 19 CCL21 - Chemokine CC motif ligand 21...
...member A (CLEC12A) (CLL1) CC chemokine receptor 7 (CCR7) (CD197) CD19 CD28 CD33 (SIGLEC3) Chemokine CC motif ligand 19 (CCL19) (ELC) Chemokine CC motif ligand 21 (CCL21) E-cadherin...
BioCentury | Nov 16, 2017
Tools & Techniques

Internal logic

...endogenous T cells, a PD-1-blocking mAb, the pro-inflammatory cytokine IL-12 and the T cell-recruiting chemokine CCL21...
...cells, the cytokine IL-12 , the chemokine CCL21 and an anti-PD-1 mAb . CCL21 - Chemokine CC motif ligand 21...
...of California San Francisco, San Francisco, Calif. University of Pennsylvania, Philadelphia, Pa. Targets CCL21 - Chemokine CC motif ligand 21...
BioCentury | Oct 31, 2017
Distillery Therapeutics

Cancer

...produce four immunostimulatory proteins as outputs -- a membrane-anchored anti- CD3 single-chain variable fragment (scFv), CCL21...
...express immunostimulatory proteins in response to transcription factors overexpressed in other solid tumors. TARGET/MARKER/PATHWAY: CD3; chemokine CC motif ligand 21 (CCL21)...
...Timothy K. Lu, Massachusetts Institute of Technology, Cambridge, Mass. email: timlu@mit.edu Karen Tkach Tuzman Massachusetts Institute of Technology CD3 Chemokine CC motif ligand 21 (CCL21) Interleukin-12...
BioCentury | Sep 1, 2016
Translation in Brief

Bacteria with a pulse

...express the lysis circuit plus the pore-forming bacterial toxin hemolysin E, the immune cell recruiting chemokine CC motif ligand 21 (CCL21)...
BioCentury | Aug 18, 2016
Distillery Techniques

Techniques: Bacteria engineered to generate pulses of therapeutic proteins in vivo

...version of the system consisting of three strains of S. enterica bacterial strains respectively expressing chemokine CC motif ligand 21 (CCL21)...
BioCentury | Jul 10, 2014
Distillery Therapeutics

Indication: Hematology

...Bone marrow transplant (BMT) Chemokine CC motif ligand 21 (CCL21); CCL25 Mouse studies suggest pretreatment of bone marrow cells with CCL21...
...reconstitution after transplant. In irradiated mice, the number of thymic endothelial cells and levels of CCL21...
...what was seen in nonirradiated mice. Transplantation of bone marrow cells pretreated with recombinant murine Ccl21...
BioCentury | Jun 19, 2014
Distillery Techniques

Technology: Markers

...and was associated with the loss of blood brain barrier integrity and upregulated expression of chemokine CC motif ligand 21 (Ccl21)...
BioCentury | Mar 5, 2001
Tools & Techniques

Vertex: Stopping metastasis

...cancer metastasis (lung, liver, lymph nodes, and bone marrow) express large amounts of CXCL12 and CCL21...
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