20:41 , Oct 10, 2017 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling A panel of 17 genomic loci could help predict the risk of PD. Genome-wide association studies in a total of 20,084 PD patients and 397,324 healthy volunteers identified associations between the disease...
00:36 , Sep 12, 2017 |  BC Extra  |  Preclinical News

Researchers identify 17 new PD risk loci

In a paper published in...
20:58 , Jul 18, 2017 |  BC Innovations  |  Distillery Techniques

Assays and screens

TECHNOLOGY: High throughput screening; activation assays; cellular assays A method of inducing...
15:49 , Mar 28, 2017 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Other A click chemistry-based method for delivering prodrugs to tumor cells could help treat cancer with minimal toxicity. The method has two steps: IV injection of an acetylated azidomannosamine analog that is activated by...
07:00 , Aug 4, 2016 |  BC Innovations  |  Product R&D

Antibiotic wisdom

While one of the biggest problems in infectious diseases is the overuse of antibiotics, few point-of-care tools are available to help physicians decide when and what to prescribe. Focusing on host genes rather than microbial...
07:00 , Aug 13, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Cathepsin B; cathepsin L (CTSL); α-synuclein (SNCA)

Neurology INDICATION: Parkinson's disease (PD) In vitro studies suggest activating cathepsin L and cathepsin B could help treat PD. In lysosomal extracts from mouse liver and brain cells, cathepsin L and cathepsin B cleaved SNCA...
07:00 , Sep 20, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bone cancer Cathepsin B In vitro and mouse studies have identified a bone-targeting doxorubicin prodrug that could help treat bone metastasis. The prodrug contains a...
08:00 , Feb 16, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Cathepsin B Mouse studies suggest inhibiting cathepsin B could help treat or prevent breast cancer metastasis. In a mouse...
07:00 , Sep 8, 2011 |  BC Innovations  |  Targets & Mechanisms

Niemann-Pick(ing) on Ebola

Teams in Europe and the U.S. have identified a host protein called Niemann-Pick disease type C1 that is required for Ebola virus to enter cells, 1,2 and both groups are developing small molecules that target...
08:00 , Mar 4, 2010 |  BC Innovations  |  Tools & Techniques

The leading edge on tumors

Two reports by a team at the University of California, San Diego describe a method for visualizing tumor margins in vivo that could help improve the precision of surgical resection and the postoperative evaluation of...