07:00 , Aug 15, 2016 |  BioCentury  |  Product Development

No antigen left behind

Amgen Inc. partnered with Advaxis Inc. to develop a personalized neoantigen therapy platform with potential to invoke a broad immune response by both stimulating the immune system on multiple fronts and delivering the full repertoire...
08:00 , Nov 13, 2014 |  BC Innovations  |  Cover Story

Boosting adjuvants

For all the talk of new vaccines, not much attention has been paid to the need for better adjuvants, which have remained stuck on alum-based products for decades. The NIH is committing up to $70...
07:00 , Aug 18, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Various

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Autoimmune disease; inflammatory disease Caspase recruitment domain family member 4 (CARD4; NOD1) An in vitro study identified inhibitors of NOD1 that...
07:00 , May 19, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Inflammatory bowel disease (IBD) BH3 interacting domain death agonist (BID); caspase recruitment domain family member 4 (CARD4; NOD1) In vitro...
07:00 , Apr 22, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Infectious disease Caspase recruitment domain family member 4 (CARD4; NOD1) In vitro and mouse studies suggest that activation of NOD1 could help treat mucosal...
07:00 , Jul 23, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Various

Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Autoimmune; inflammatory disease Baculoviral IAP repeat-containing 2 (BIRC2; cIAP1); baculoviral IAP repeat-containing 3 (BIRC3; cIAP2); caspase recruitment domain family member 4 (CARD4; NOD1); caspase recruitment...
08:00 , Dec 11, 2008 |  BC Innovations  |  Distillery Therapeutics

This week in therapeutics

The Distillery: Therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Inflammatory bowel disease (IBD) Nucleotide-binding oligomerization domain containing 1 (NOD1; CARD4); chemokine (CC motif) receptor 6 (CCR6) Studies in mice suggest...
08:00 , Feb 28, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Other Adjuvant Caspase recruitment domain family, member 4 (CARD4; Nod1); caspase recruitment domain family, member 15 (CARD15; Nod2) Studies in cell culture...