07:00 , Jul 19, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD); Huntington's disease (HD) Caspase-6 (CASP6; MCH2) In vitro and cell culture studies identified a peptide-based inhibitor of CASP6,...
07:00 , Jun 30, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Stroke Caspase-6 (CASP6; MCH2); CASP9 (MCH6) In vitro and rodent studies suggest inhibiting CASP9 or CASP6 after stroke could improve outcomes. In a rat stroke...
08:00 , Jan 6, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Huntington's disease (HD) Caspase-3 (CASP3; CPP32); caspase-6 (CASP6; MCH2); huntingtin (HTT) A study in cell culture identified small molecule dual CASP3 and CASP6 inhibitors that...
08:00 , Nov 12, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Procaspase-3; procaspase-6; caspase-3 (CASP3; CPP32); caspase-6 (CASP6; MCH2) Studies in cell culture suggest that small molecule activators of procaspases could help treat cancer. High...
07:00 , Apr 16, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Huntington's disease (HD) Caspase-6 apoptosis-related cysteine peptidase (CASP6; MCH2) In vitro studies identified sulfonamide isatin Michael acceptor (IMA) analogs that could...
08:00 , Feb 26, 2009 |  BC Innovations  |  Cover Story

Genentech's new parADigm

A study by a team at Genentech Inc. proposes a new mechanism for Alzheimer's disease pathogenesis by outlining a process that could be an early step in the neurodegenerative disorder. 1 The work also identifies...
08:00 , Feb 26, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) Tumor necrosis factor receptor superfamily, member 21 (TNFRSF21; DR6); caspase-6 apoptosis-related cysteine peptidase (CASP6; MCH2); amyloid...