BioCentury | Dec 6, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: November 2018

New Therapeutic Targets and Biomarkers: November 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during November. Therapeutic targets are defined as any protein, gene or other molecule...
BioCentury | Nov 26, 2018
Distillery Therapeutics

Cancer

INDICATION: Chronic myelogenous leukemia (CML) Mouse and cell culture studies suggest inhibiting CPT1B could help treat CML in obese patients. In a mouse model of diet-induced obesity, levels of CPT1B on NK cells were higher...
BioCentury | Nov 15, 2018
Product R&D

Tempest takes PPAR alpha into cancer

...Calif. Targets BATF3 - Basic leucine zipper ATF-like transcription factor CD36 (GPIV) CPT1A (CPT1) - Carnitine palmitoyl transferase 1...
BioCentury | Oct 25, 2018
Distillery Techniques

Assays and screens

...other classes of drugs. The generic antihistamine cyproheptadine is marketed to treat allergies. The generic carnitine palmitoyl transferase 1...
BioCentury | Jun 13, 2018
Distillery Therapeutics

Cancer

...FASgen Inc. has the CPT1A inhibitor FAS 89B in preclinical testing to treat obesity. TARGET/MARKER/PATHWAY: Carnitine palmitoyl transferase 1...
...Yihai Cao, Karolinska Institute, Stockholm, Sweden email: yihai.cao@ki.se Sandi Wong Karolinska Institute Shanghai University of Traditional Chinese Medicine Shenzhen University Carnitine palmitoyl transferase 1...
BioCentury | May 4, 2018
Preclinical News

PPAR agonist-induced fatty acid metabolism boosts tissue regeneration

...higher expression of genetic targets of PPAR delta, including genes involved in FAO such as carnitine palmitoyl transferase 1...
...Mass.) (see BioCentury Innovations, April 6, 2017) . Sandi Wong Massachusetts Institute of Technology Whitehead Institute for Biomedical Research Carnitine palmitoyl transferase 1...
BioCentury | Sep 5, 2016
Clinical News

Perhexiline: Phase IIb started

...Molecular target: Carnitine palmitoyl transferase 1 (CPT1) ; Carnitine palmitoyl transferase 2 (CPT2) Description: Small molecule inhibitor of carnitine palmitoyl transferase 1...
BioCentury | May 5, 2016
Distillery Therapeutics

Therapeutics: Carnitine palmitoyl transferase 1 (CPT1)

...Inc. has FAS 89B , a CPT1 inhibitor, in preclinical testing to treat obesity. TARGET/MARKER/PATHWAY: Carnitine palmitoyl transferase 1...
BioCentury | Mar 10, 2016
Distillery Therapeutics

Therapeutics: Carnitine palmitoyl transferase 1 (CPT1); CPT2; v-myc myelocytomatosis viral oncogene homolog (MYC; c-Myc)

...has FAS 89B , a selective CPT1 inhibitor, in preclinical testing to treat obesity. TARGET/MARKER/PATHWAY: Carnitine palmitoyl transferase 1...
BioCentury | Apr 28, 2014
Finance

Targeted generic

...dogged perhexiline, a generic it is repurposing for hypertrophic cardiomyopathy. The small molecule inhibitor of carnitine palmitoyl transferase 1...
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