BioCentury | Aug 27, 2020
Product Development

Freenome maps path forward for blood-based cancer screenings with $270M C round

...specificity of 94%. Two other blood-based tests, plasma carcinoembryonic antigen...
BioCentury | Jun 2, 2020
Product Development

Sanofi makes case for why its first cancer drug in a decade can take on Darzalex

...subgroup. First-in-class antibody-drug conjugate SAR408701, which targets CEACAM5, builds up the lung cancer pillar. The CEA...
...the specific types of technologies or therapeutics it’s targeting for BD. Targets CEACAM5 (CD66e) - Carcinoembryonic antigen-related...
...tyrosine phosphatase TGFβ - Transforming growth factor β Lauren Martz, Senior Editor Libtayo, cemiplimab-rwlc (REGN2810, SAR439684) Sanofi Carcinoembryonic antigen (CEA)-related cell adhesion molecule 5 (CEACAM5) (CD66e) CD38 Programmed...
BioCentury | Jan 25, 2020
Targets & Mechanisms

CAR T strategies for cracking the code in solid tumors

...1 (PD-L1) (B7-H1) (CD274) CD70 (CD27L) Splice variant v6 of CD44 (CD44v6) B7-H3 (CD276) AXL receptor tyrosine kinase (AXL) (UFO) Carcinoembryonic antigen (CEA) Claudin...
BioCentury | Jan 11, 2020
Finance

Why buysiders say 2020 could be the year of the CNS

...tumors (GISTs). Roche’s Phase I bispecifics include a CD3 x CD20 mAb and CD3 x CEA...
...IL2RA) - Interleukin-2 receptor α chain CD122 (IL2RB) - Interleukin-2 receptor β chain CEA - Carcinoembryonic antigen...
BioCentury | Dec 3, 2019
Politics & Policy

Democratic drug pricing bill would kill 100 drugs in 10 years, White House economic advisers say

...of Economic Advisers (CEA) predicted that H.R. 3 would have catastrophic effects on drug development. CEA...
...of the total number of drugs expected to enter the market during that time.” The CEA’s...
...of H.R. 3 on investments in biotech companies (see “Debating the Fate of Innovation” ). CEA’s...
BioCentury | Nov 6, 2019

Peptide inhibitors of a histone chaperone for osteosarcoma and breast cancer

...Atomic Energy Commission, Gif-sur-Yvette, France email: raphael.guerois@cea.fr CONTACT: Françoise Ochsenbein, same affiliation as above email: francoise.ochsenbein@cea.fr Claire...
BioCentury | Oct 31, 2019

Human symbiont-derived antimicrobial peptide for Gram-positive infections

...la Recherche Scientifique (CNRS), Marseille, France email: mickael.lafond@univ-amu.fr CONTACT: Victor Duarte, CNRS, Grenoble, France email: victor.duarte@cea.fr Claire...
BioCentury | Oct 19, 2019
Product Development

Tracking the rise and fall of next-generation checkpoint targets for cancer

...Ltd. (Tel Aviv:KTOV; NASDAQ:KTOV) plans to restart development of anti-carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, CD66a...
...Bringing up the rear CEACAM1 was ahead of TIGIT in 2015, with one candidate, the anti-CEACAM1...
...Ltd. (NASDAQ:CGEN; Tel Aviv:CGEN) moved into Phase I in 2018. Targets CD80 (B7-1) CEACAM1 (CD66a)- Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1...
BioCentury | Sep 27, 2019
Politics, Policy & Law

Trump administration to modernize flu vaccines via government buying power

...vaccines signed by President Donald Trump on September 19, and a Council of Economic Advisers (CEA...
...and security functions and inflict trillions of dollars in costs on the U.S. economy, the CEA...
...the Biomedical Advances Research and Development Authority (BARDA), told BioCentury. Bright, the EO and the CEA...
BioCentury | Jun 27, 2019
Distillery Therapeutics

4-1BBL fusion protein boosts T cell bispecific Abs for gastric cancer and lymphoma

...of gastric cancer, the FAP-targeted fusion protein plus RG7802, a T cell bispecific mAb against CEA...
...mouse model of lymphoma. Roche has RG7802 in Phase I testing for colorectal cancer and CEA-positive...
...Umaña, Roche Innovation Center Zurich, Zurich, Switzerland email: pablo.umana@roche.com Claire Quang CEA-TCB (RG7802, RO6958688) RG6026 CD3 Roche 4-1BB ligand (4-1BBL) (TNFSF9) (CD137L) Carcinoembryonic antigen (CEA) CD20...
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