...the company; the pharma has since declined the option. BLD-2660, which inhibits CAPN1, CAPN2 and CAPN9...
...lack of CAPN9 prevented a TGFβ-induced pathway that contributes to fibrosis development. Mice without functional CAPN9...
...on future financing plans. Targets: CAPN1 - Calpain 1; CAPN2 - Calpain 2; CAPN9 - Calpain 9...

...DISEASE CATEGORY: Pulmonary; hepatic; cardiovascular INDICATION: Pulmonary fibrosis; liver fibrosis; cardiac fibrosis Inhibition of CAPN9 could...
...treat fibrosis by blocking a TGFβ-induced pathway that contributes to fibrosis development. Two tool compound CAPN9...
...into myofibroblasts -- a process linked to fibrosis development. Mice with a loss-of-function mutation in CAPN9...

...Johns Hopkins University reported in a Science Translational Medicine paper that inhibition or lack of CAPN9...
...suggesting the cysteine protease as a new target to treat the disease. Mice without functional CAPN9...
...ADAR (ADAR1) - Adenosine deaminase RNA-specific; DYRK1A - Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; CAPN9 - Calpain 9...