07:00 , Aug 25, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Calpain 6 (CAPN6)

Cardiovascular disease INDICATION: Atherosclerosis Patient sample and mouse studies suggest inhibiting CAPN6 could help treat atherosclerosis. In patients, CAPN6 expression on macrophages in atheromas was associated with disease severity. In a mouse model of atherosclerosis,...
17:39 , Dec 18, 2014 |  BC Innovations  |  Distillery Techniques

Techniques: Chromosome 11 open reading frame 30 (C11orf30),calpain small subunit 1 (CAPNS1; CAPN14), signal transducer and activator oftranscription 6 (STAT6)

Bio Markers TECHNOLOGY: Markers Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE. In a discovery cohort of 603 EoE patients and 3,637 controls, variants at C11orf30...
07:00 , Jul 31, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD); neurology Calpain; calpastatin Mouse studies suggest inhibiting calpain could help treat AD and other neurodegenerative tauopathies. In a transgenic mouse tauopathy model,...
08:00 , Jan 9, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Nerve injury Calpastatin; calpain In vitro and mouse studies suggest calpastatin, an inhibitor of the proteinase calpain, could help treat nerve injury. In cultured mouse...
07:00 , Apr 5, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Calpain 2 (CAPN2) In vitro and mouse studies suggest CAPN2 inhibitors could help treat breast cancer. In a mouse mammary cancer cell line,...
07:00 , Nov 3, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Hypertension Calpain small subunit 1 (CAPNS1; CAPN4) In vitro and rodent studies suggest inhibiting calpain could help treat pulmonary arterial hypertension (PAH). In smooth...
07:00 , Nov 3, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune disease IL-17C; IL-17 receptor E (IL-17RE) Mouse studies suggest antagonizing IL-17C or its receptor, IL-17RE, could help treat autoimmune diseases. In mice with...
07:00 , Aug 26, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Calpain 1 (CAPN1); CAPN2 In vitro and mouse studies identified analogs of CAPN1 and CAPN2 inhibitors that cross the blood brain barrier (BBB) and...
07:00 , Aug 12, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Gastrointestinal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Gastrointestinal disease Gastrointestinal injury Calpain 8 (CAPN8); CAPN9 Mouse studies suggest that upregulating CAPN8 and CAPN9 in the gastrointestinal tract could help treat stress-induced gastrointestinal injury....
07:00 , Oct 22, 2009 |  BC Innovations  |  Distillery Techniques

Technology: Drug delivery

Approach Summary Licensing status Publication and contact information Drug delivery Delivery of low-molecular weight therapeutics to the retina RNAi-mediated suppression of the tight junction protein claudin-5 could improve delivery of therapeutics across the blood retina...