07:00 , Apr 9, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Calnexin (CANX)

Infectious disease INDICATION: Fungal infection In vitro and mouse studies suggest a vaccine based on fungal CANX could help protect against fungal infection. Assays in transgenic mouse CD4+ T cells expressing a fungi-specific T cell...
07:00 , Sep 25, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Gaucher's disease DnaJ homolog subfamily B member 11 (DNAJB11; ERdj3); glucocerebrosidase (GBA; GCase) Mouse studies suggest inhibiting ERdj3 could help treat Gaucher's disease, a...
07:00 , May 20, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Metabolic disease Gaucher's disease Calnexin (CANX); glucocerebrosidase (GBA; GCase); ryanodine receptor (RyR) A study in cell culture suggests that increasing calcium levels in the endoplasmic reticulum...
08:00 , Feb 28, 2008 |  BC Innovations  |  Targets & Mechanisms

A third way for lysosomal treatments

Scientists at The Scripps Research Institute have found that generic small-molecule calcium channel blockers for hypertension can restore enzyme function in lysosomal storage disorders. But human testing is needed to determine how they fit in...
07:00 , Jun 4, 2001 |  BC Week In Review  |  Company News

National Human Genome Research Institute, Yale University other research news

NHGRI researchers published in Nature Medicine an artificial neural network (ANN) method to classify cancers according to gene expression. Using 23 small round blue cell tumor (SRBCT) samples and 40 SRBCT cell lines, researchers trained...