01:40 , Aug 18, 2018 |  BioCentury  |  Regulation

Pediatric push

FDA has endorsed extrapolation of therapeutic efficacy from adults to children for new drugs to treat partial onset seizures in a draft guidance and is now discussing in public meetings whether the approach can be...
01:46 , May 5, 2018 |  BioCentury  |  Product Development

Rebuilding Biogen’s brain

Biogen Inc. is still a long way from a full rebuild of its pipeline, with an Alzheimer’s disease-laden Phase III lineup that needs to diversify. But there’s progress in the early- to mid-stage programs where...
19:49 , Jan 25, 2018 |  BC Innovations  |  Translation in Brief

Remote-controlled CARs

A three-way academic collaboration has developed an ultrasound-based method for controlling both when and where CAR T cells are active. The technology could move the field a step beyond designs that incorporate only on- or...
00:53 , Jan 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Epilepsy Cell culture and rat studies identified a benzodiazepine-based triple-inhibitor of CACNA1G , CACNA1H and CACNA1I that could help treat epilepsy. Chemical synthesis and testing in HEK cells expressing the three calcium channels identified...
07:00 , Jun 30, 2016 |  BC Innovations  |  Targets & Mechanisms

AChE revisited

Selina Koch and Mark Zipkin, Staff Writers  Neuro-Bio Ltd. has identified a peptide derived from AChE - the enzyme responsible for breaking down acetylcholine - and believes the fragment is the main pathological driver in...
08:00 , Feb 29, 2016 |  BioCentury  |  Regulation

Competitive consequences

Whatever the reason FDA refused to file an NDA for Catalyst Pharmaceuticals Inc .'s Firdapse amifampridine, the delay could allow a competitor with a less expensive form of the molecule to gain ground in a...
08:00 , Dec 11, 2014 |  BC Innovations  |  Targets & Mechanisms

PIEZO de resistance

A pair of recently identified calcium channels- PIEZO1 and PIEZO2-control the response of cartilage to heavy loads and offer new targets for joint injury and osteoarthritis, according to findings from a team at Duke University...
07:00 , Oct 31, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Viral infection Calcium channel voltage-dependent a2/d subunit 2 (CACNA2D2) In vitro and mouse studies suggest voltage-gated calcium channel inhibitors could help treat or prevent...
07:00 , Oct 10, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Assays & screens

Approach Summary Licensing status Publication and contact information Assays & screens Method for expressing large genes in cardiomyocytes A method for expressing large genes in cardiomyocytes could be useful for creating new models and assays....
07:00 , Aug 8, 2013 |  BC Innovations  |  Targets & Mechanisms

CRACking pancreatitis

The handful of companies pursuing CRAC inhibitors for immunological disorders have a new indication to consider-acute pancreatitis. New findings from Cardiff University 1 show that the target plays a central role in the painful and...