00:53 , Jan 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Epilepsy Cell culture and rat studies identified a benzodiazepine-based triple-inhibitor of CACNA1G, CACNA1H and CACNA1I that could help treat epilepsy. Chemical synthesis and testing in HEK cells expressing the three calcium channels identified a pyridodiazepine...
07:00 , Jun 11, 2012 |  BioCentury  |  Emerging Company Profile

Xdynia: T type relief

Xdynia LLC spun out from Tau Therapeutics Inc. this year to develop oral small molecule inhibitors of a specific subset of voltage-dependent T type calcium channels that play a prominent role in pain signal transduction....
07:00 , Jun 11, 2009 |  BC Innovations  |  Cover Story

Eat, sleep, lose weight

Researchers at Merck & Co. Inc.may have found a way to tackle obesity by antagonizing T-type calcium channels, which are involved in sleep regulation. In rodents, the approach reduced diet-induced weight gain and increased lean...