PharmaMar will likely need to conduct a new study of Zepzelca to gain its full approval after the drug failed to show a survival benefit in a potentially confirmatory Phase III trial to treat small...

Icosavax believes its computationally designed virus-like particles will open the clinically validated vaccine modality to a broader range of infectious diseases. The company expects its $51 million series A round, announced Thursday, to carry its...

AB Sciences drops masitinib for melanoma AB Science S.A. (Euronext:AB) halted development of masitinib for metastatic melanoma despite reporting that the product led to a 33.3% overall response rate (ORR), the primary endpoint in the...

Takeda Pharmaceutical Co. Ltd. (Tokyo:4502; NYSE:TAK) Andrew Plump has become president of R&D, according to the pharma's website. He was Takeda's CMO and CSO since 2015. Wolfram Nothaft, former head of global clinical development at...

Pfizer Inc. (NYSE:PFE) said FDA granted pediatric exclusivity to its blockbuster neurology drug Lyrica pregabalin, extending the product's patent protection by six months to June 30, 2019. Lyrica is approved in the U.S. to treat...

New Therapeutic Targets and Biomarkers: September 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in September. Therapeutic targets are defined as any protein, gene or other molecule...

INDICATION: Pain Mouse studies suggest inhibiting the USP5-CACNA1H interaction could help treat postsurgical pain. In a mouse model of incisional pain, shRNA targeting of USP5 or systemic knockout of CACNA1H decreased mechanical allodynia compared with...

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...

Genentech and Xenon have reported that the key to finding a selective Nav1.7 blocker is devising a better screen, not using a bigger compound library. By retooling a commonly used assay, the partners identified a...