19:11 , May 8, 2017 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Mouse studies suggest inhibiting the calcium channel L-type could help treat MS. In the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, a calcium channel L-type inhibitor decreased MS symptom scores,...
07:00 , Oct 10, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Assays & screens

Approach Summary Licensing status Publication and contact information Assays & screens Method for expressing large genes in cardiomyocytes A method for expressing large genes in cardiomyocytes could be useful for creating new models and assays....
07:00 , Aug 8, 2013 |  BC Innovations  |  Tools & Techniques

A new wave of arrhythmia assays

Cardiotoxicity testing has plagued drug developers for years as the principal preclinical test, the hERG assay, and the primary clinical marker, prolonged QT, are relatively poor predictors of proarrhythmic potential. Now, information about the different...
08:00 , Nov 18, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Calcium channel L-type; calcium channel voltage-dependent L type a1D subunit (CACNA1D; Cav1.3) Mouse studies suggest that L-type calcium channel antagonists could help...
07:00 , Aug 6, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Cognitive dysfunction Calcium channel L-type In vitro and rat studies suggest that agonizing L-type voltage-dependent calcium channels could help enhance memory and treat cognitive dysfunction....
07:00 , Apr 30, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) Acetylcholinesterase (AChE); calcium channel L-type An SAR study characterized a series of tacrine-^dihydropyridine hybrids called tacripyrines that...
08:00 , Feb 19, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Hypertension Calcium channel, L-type (LTCC) An SAR study characterized a series of anthracene-maleimide compounds that block LTCC and could...
08:00 , Feb 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Calcium channel, L-type (LTCC) In vitro studies showed that activating LTCCs may help treat type 1 diabetes....