BioCentury | Apr 4, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: March 2019

...disorder aspartylglucosaminuria Neurogene Inc. Emerging Company Profile Infectious disease Cryptosporidium Cryptosporidium parvum calcium-dependent protein kinase 1 (C. parvum CDPK1...
...In vitro , cell culture and mouse models identified two carboxamide-based inhibitors of C. parvum CDPK1...
BioCentury | Mar 13, 2019
Distillery Therapeutics

Two inhibitors of CDPK1 to treat the infection

...In vitro , cell culture and mouse models identified two carboxamide-based inhibitors of C. parvum CDPK1...
...testing the compounds in models of Cryptosporidium infection. TARGET/MARKER/PATHWAY: Cryptosporidium parvum calcium-dependent protein kinase 1 ( C. parvum CDPK1...
...CONTACT: Robert Hackman, same affiliation as above email:erkang@uw.edu Claire Quang University of Washington Cryptosporidium parvum calcium-dependent protein kinase 1 (C. parvum CDPK1) Cryptosporidium...
BioCentury | May 4, 2018
Preclinical News

New method could identify new antimalarial targets

A new method for large-scale screening of the malaria genome could identify pathogenic genes and provide drug developers with previously unexplored targets to investigate as antimalarial therapeutics. The Science study was led by researchers at...
BioCentury | Jul 14, 2016
Distillery Therapeutics

Therapeutics: Toxoplasma gondii calcium-dependent protein kinase 1 (CDPK1)

...disease INDICATION: Toxoplasmosis In vitro and mouse studies identified a pyrazolopyrimidine-based inhibitor of Toxoplasma gondii CDPK1...
...synthesis and in vitro testing of pyrazolopyrimidine analogs yielded one compound that inhibited T. gondii CDPK1...
...steps could include testing and improving safety and efficacy of the compound. TARGET/MARKER/PATHWAY: Toxoplasma gondii calcium-dependent protein kinase 1 (CDPK1)...
BioCentury | Jun 7, 2012
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4; PF07_0072) Studies in cell culture, mosquitoes and mice suggest antagonizing PfCDPK4 could...
BioCentury | May 20, 2010
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum calcium-dependent protein kinase 5 (PfCDPK5; PF13_0211) In vitro studies suggest that inhibiting PfCDPK5 could help treat malaria. Compared with wild-type P....
BioCentury | May 6, 2010
Distillery Therapeutics

Indication: Infectious disease

...inhibiting Toxoplasma gondii CDPK1 could help treat toxoplasmosis. In vitro, bumped kinase inhibitors (BKIs) bound CDPK1...
BioCentury | Jun 26, 2008
Cover Story

New Area in Malaria

...Winzeler's group recently used library screening to identify an inhibitor of a different Plasmodium kinase, calcium-dependent protein kinase 1...
BioCentury | May 22, 2008
Distillery Therapeutics

This Week in Therapeutics

...Indication Target/ marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum calcium-dependent protein kinase 1...
Items per page:
1 - 9 of 9