07:00 , Jul 14, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Toxoplasma gondii calcium-dependent protein kinase 1 (CDPK1)

Infectious disease INDICATION: Toxoplasmosis In vitro and mouse studies identified a pyrazolopyrimidine-based inhibitor of Toxoplasma gondii CDPK1 that could help treat toxoplasmosis. Chemical synthesis and in vitro testing of pyrazolopyrimidine analogs yielded one compound that...
07:00 , May 6, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Infectious disease Calcium-dependent protein kinase 1 (CDPK1) In vitro studies suggest that inhibiting Toxoplasma gondii CDPK1 could help treat toxoplasmosis. In vitro, bumped kinase...
07:00 , Jun 26, 2008 |  BC Innovations  |  Cover Story

New Area in Malaria

Development of malaria therapeutics has been stymied by poor understanding of drug targets and limited corporate interest in picking up preclinical compounds with therapeutic promise. At the same time, the parasite has shown mounting resistance...
07:00 , May 22, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) In vitro studies suggest that 2,6,9-trisubstituted purine inhibitors of PfCDPK1 could...