BioCentury | Aug 25, 2016
Distillery Therapeutics

Therapeutics: C. albicans cytochrome bc1

...to fluconazole and other triazole-based drugs. In a mouse model of fluconazole-resistant candidiasis, knockout of C. albicans cytochrome bc1...
...in in vitro enzymatic assays and fluconazole-resistant C. albicans culture identified a compound that inhibited C. albicans cytochrome bc1...
...IC50 values of 0.28 μM and 0.38 μM, respectively, and was 5.6-fold more selective for C. albicans cytochrome bc1...
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