BioCentury | Mar 27, 2014
Targets & Mechanisms

Insights into ependymoma

...the team determined that eight of the nine cases involved a fusion between chromosome 11 open reading frame 95 ( C11orf95...
...lacked the C11orf95-RELA translocation. The fusions were C11orf95- YAP1 ( yes-associated protein 1 ) and C11orf95...
...C11orf95 or RELA, showed no tumor growth and survived. Implantation of neural stem cells expressing C11orf95-YAP1...
BioCentury | Mar 13, 2014
Distillery Therapeutics

Indication: Cancer

...oncogene homolog A (RELA; p65); chromosome 11 open reading frame 95 (C11orf95) Patient sample and cell culture studies suggest targeting a C11orf95-RELA...
...ependymomas. Genetic analyses of patient brain tumor samples identified an oncogenic fusion between RELA and C11orf95...
...cases of posterior fossa ependymomas. In nude mice, implants of neural stem cells expressing the C11orf95-RELA...
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