BioCentury | Mar 27, 2021
Translation in Brief

Lentigen’s trispecific CAR Ts; plus a bispecific antiviral COVID-19 mAb, Wild Biotech, Kancera and more

Researchers from Miltenyi Biotec GmbH’s Lentigen unit created trispecific CAR T cells, dubbed duoCAR T cells, directed against CD19, CD20 and CD22 that eliminated antigen-heterogeneous B cell tumors in...
BioCentury | Jan 23, 2021
Emerging Company Profile

ONK’s CAR NK cells hit the TRAIL

ONK thinks its engineered TRAIL variants will make CAR NK cells more potent and resistance-proof against both hematological and solid cancers.  The company, which spun out of National University of Ireland Galway in 2015, has applied...
BioCentury | Oct 27, 2020
Distillery Therapeutics

FAP inhibition for the treatment of osteoporosis

DISEASE CATEGORY: Musculoskeletal INDICATION: Osteoporosis The endogenous bone growth factor CLEC11A and other inhibitors of FAP could treat osteoporosis. In cultures of mouse primary bone marrow cells, a tool compound FAP inhibitor reduced osteoclast differentiation. In...
BioCentury | Aug 22, 2020
Translation in Brief

IPD’s synthetic bio unlocks target combos for cell therapy; plus Merck’s oral STING agonist, Surrozen’s regenerative therapy and more

Synthetic switches aim T cells at cells expressing antigen combos David Baker’s team at University of Washington’s Institute for Protein Design published a study in Science showing its synthetic protein switches can direct T cells...
BioCentury | Jun 13, 2020
Translation in Brief

OSE identifies myeloid checkpoint target; plus a call from NCI for COVID-19 test proposals, Sinopharm vaccine data and more

mAbs against new myeloid checkpoint OSE Immunotherapeutics S.A. (Euronext:OSE) has identified CLEC1A, a carbohydrate-binding protein, as a tumor myeloid checkpoint target, and has generated mAbs that prevent CLEC1A from binding its ligand on tumor cells....
BioCentury | May 29, 2020
Distillery Therapeutics

Blocking platelet activation for acetaminophen-induced liver failure

DISEASE CATEGORY: Hepatic INDICATION: Liver failure Inhibiting signaling by the platelet activating receptor CLEC1B could treat acetaminophen-induced liver failure. mRNA levels of PDPN, the cognate ligand of CLEC1B, were higher in tissue from acetaminophen-injured human...
BioCentury | Jan 31, 2020
Distillery Therapeutics

CLEC14A-positive stem cell transplants for muscle regeneration

DISEASE CATEGORY: Musculoskeletal INDICATION: Musculoskeletal Transplantation with muscle-derived CLEC14A-positive stem cells could regenerate muscle following injury, despite lacking expression of known myogenic regulator PAX7. The myogenic cells were isolated from muscle fiber fragments that underwent...
BioCentury | Jan 30, 2020
Company News

As Spinraza’s sales level off, Biogen presses ahead with aducanumab plans

Although Biogen’s earnings report suggests sales of SMA therapy Spinraza have plateaued, the company signaled its continued optimism that FDA will approve another potential blockbuster, its Alzheimer’s disease treatment aducanumab. Revenues from Spinraza nusinersen dipped...
BioCentury | Dec 3, 2019
Clinical News

Biogen plotting next steps in lupus after latest readout

As Biogen seeks to build its immunology franchise, it became the latest company to post encouraging data in lupus, with BIIB059 meeting the primary endpoints in a Phase II trial to treat both cutaneous lupus...
BioCentury | Jul 24, 2019
Distillery Therapeutics

Simultaneous CLEC5A and TLR2 inhibition for dengue

DISEASE CATEGORY: Infectious disease INDICATION: Dengue fever; viral hemorrhagic fever Simultaneously blocking CLEC5A and TLR2, both pattern recognition receptors linked to microbial infections, could improve survival following dengue virus infection. The inflammatory response to dengue...
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