08:00 , Feb 19, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: c-jun N-terminal kinase 2 (JNK2; MAPK9); JNK3 (MAPK10)

Neurology INDICATION: Neurology In vitro studies have identified aminopyrazole-based JNK2 /3-selective inhibitors that could help treat neurodegenerative diseases linked to neuronal oxidative stress. In vitro, the lead compound inhibited JNK2, JNK3 and JNK1 at IC50...
07:00 , Sep 13, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) c-Jun N-terminal kinase 3 (JNK3; MAPK10); b-amyloid 42 In vitro and mouse studies suggest JNK3 inhibition could help treat AD. In mouse...
08:00 , Dec 17, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology c-Jun N-terminal kinase (JNK) Studies in cell culture and in rodents identified biaryl-substituted aminopyrimidine JNK inhibitors that could help treat neurodegenerative diseases. Biochemical and...
07:00 , Apr 2, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Various

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Cardiovascular, cancer c-jun N-terminal kinase 3 (JNK3; MAPK10); chemokine CXC motif ligand 12 (CXCL12; SDF-1) In vitro studies suggest that targeting...
07:00 , Oct 30, 2008 |  BC Innovations  |  Targets & Mechanisms

Block JNK at the dock

A team of U.S. researchers has described a new mitogen-activated protein kinase 8 ( JNK ; MAPK8 ) inhibitor that targets JNK's substrate docking site-instead of its ATP binding site-to treat type 2 diabetes. 1...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

High probability pathways

High probability pathways...
07:00 , Aug 24, 1998 |  BC Week In Review  |  Company News

Vertex other research news

VRTX published in Structure the three-dimensional atomic structure of the JNK3 transcription factor, which regulates gene expression in certain parts of the brain in response to intercellular signals. The enzyme is a potential target for...