BC Innovations | May 28, 2019
Distillery Therapeutics

Dual activation of JNK1 and JNK2 for STK11-deficient lung cancer

DISEASE CATEGORY: Cancer INDICATION: Lung cancer Patient sample, cell culture and mouse studies suggest dual activation of JNK1 and JNK2 could help treat STK11-deficient squamous cell carcinoma (SCC) of the lung. In patients, low tumor...
BC Innovations | Feb 19, 2015
Distillery Therapeutics

Therapeutics: c-jun N-terminal kinase 2 (JNK2; MAPK9); JNK3 (MAPK10)

Neurology INDICATION: Neurology In vitro studies have identified aminopyrazole-based JNK2 /3-selective inhibitors that could help treat neurodegenerative diseases linked to neuronal oxidative stress. In vitro, the lead compound inhibited JNK2, JNK3 and JNK1 at IC50...
BC Innovations | Feb 12, 2009
Distillery Therapeutics

Indication: Autoimmune disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune c-jun N-terminal kinase 1 (JNK1); JNK2 (MAPK9); tumor necrosis factor-a (TNF-a) A study in mice suggests that inhibiting hematopoietic...
BC Innovations | Oct 30, 2008
Targets & Mechanisms

Block JNK at the dock

A team of U.S. researchers has described a new mitogen-activated protein kinase 8 ( JNK ; MAPK8 ) inhibitor that targets JNK's substrate docking site-instead of its ATP binding site-to treat type 2 diabetes. 1 The targeting...
BioCentury | Apr 23, 2007
Tools & Techniques

High probability pathways

High probability pathways Pathway Genes in pathway (A) Pathway components [Ranking] (A) [5] Fibroblast growth factor (FGF) signaling MAP2K4; FGFR4; FGFR1; MAPK14; MAPK8; MAPK9; FGFR3; MAP3K6; MAP3K2; MAPK11; PRKCB1; RAF1; PRKCA; PRKCH; MAPK13; AKT3; PRKCE;...
BC Week In Review | Mar 13, 2000
Company News

Isis other research news

ISIP published in Blood that activation of JNK1 and JNK2 in red blood cell precursors led to apoptosis, and that erythropoietin prevented such effects; they also published in Biochemical Pharmacology the inhibition of hypoxia/reoxygenation-induced apoptosis...
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