23:11 , Mar 20, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Basal cell carcinoma (BCC) Cell culture and mouse studies suggest inhibition of SRF or its co-activator MLK1 could help treat drug-resistant BCC. In one human and two mouse SMO inhibitor-resistant BCC cell lines, a...
20:11 , Sep 26, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Insomnia; neurology Mouse studies suggest activation of LHX6 -expressing neurons in the ventral zona incerta could help treat sleep disorders. In mice, levels of the activation marker c-fos were higher in LHX6-positive neurons in...
19:21 , Jul 31, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer's disease (AD) Mouse studies suggest inhibiting the FOSB / HDAC1 axis could help treat AD. In dentate gyrus tissue samples from a mouse model of AD, levels of a truncated FOSB isoform were...
16:41 , Jun 14, 2017 |  BC Innovations  |  Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Cachexia Mouse studies suggest inhibiting CGRP -expressing neurons could help treat cancer-associated anorexia and malaise. In a mouse model of the indication, levels of the neuronal activation marker c-fos were higher in CGRP-expressing parabrachial...
20:10 , May 25, 2017 |  BC Innovations  |  Translation in Brief

Youthful memories

Alkahest Inc. co-founder and Stanford University researcher Tony Wyss-Coray has followed up his earlier discovery of blood factors in the elderly that contribute to cognitive decline by finding an umbilical cord blood factor that may...
15:49 , Mar 28, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Chronic myelogenous leukemia (CML)...
07:00 , Oct 10, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Skin cancer Not applicable In vitro and mouse studies suggest treating skin inflammation could help treat or prevent skin squamous cell carcinoma (SCC). In mice,...
07:00 , Mar 18, 2013 |  BioCentury  |  Emerging Company Profile

gIcare: Colonoscopy comfort

gIcare pharma Inc. is developing a pipeline of non-sedating colonic analgesic compounds to provide new and lower cost alternatives for pain management during colonoscopy. Sedation during endoscopy has become routine practice among gastroenterologists, even though...
07:00 , Mar 17, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Serum response factor (c-fos serum response element-binding transcription factor; SRF) Studies in patient samples and in mice suggest that...
07:00 , Apr 22, 2002 |  BC Week In Review  |  Company News

Toray Industries Inc. other research news

Researchers published in Nature evidence that interferon-beta and c-Fos , which are expressed in response to activation of RANKL (receptor activator of NF-kB ligand), constitute an autoregulatory loop for maintenance of bone homeostasis. Cells treated...