16:38 , Jul 18, 2019 |  BC Innovations  |  Distillery Therapeutics

Inhibition of BACH1 or the genes it controls for metastatic lung cancer

DISEASE CATEGORY: Cancer INDICATION: Lung cancer Inhibiting the pro-metastatic transcription factor BACH1 or its gene targets MCT1, HMOX1, HK2 and GADPH could treat metastatic lung cancer. In patients with metastasized lung cancer, levels of BACH1...
14:28 , Mar 19, 2019 |  BC Innovations  |  Distillery Therapeutics

Inhibiting BACH1 sensitizes triple-negative breast cancer to metformin

DISEASE CATEGORY: Cancer INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest BACH1 inhibitors could sensitize triple-negative breast cancer (TNBC) to metformin. In tumor samples from patients with TNBC and basal-like breast cancer,...
23:44 , Oct 9, 2006 |  BC Extra  |  Clinical News

Researchers identify breast cancer risk gene

Researchers from U.K.'s Institute of Cancer Research and colleagues published in Nature Genetics that women with mutations in the BRIP1 (BACH1) gene have twice the normal risk of breast cancer (p=0.012). Like other breast cancer...