08:00 , Mar 10, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Bromodomain containing 9 (BRD9)

Cancer INDICATION: Acute myelogenous leukemia (AML) Cell culture and mouse studies identified two naphthyridinone-based BRD9 inhibitors that could help treat AML. Fragment screening, chemical synthesis on hits and in vitro assays identified two naphthyridinone analogs that bound...