BioCentury | Nov 10, 2014
Clinical News

Dabrafenib: Additional Phase III data

Additional data from the open-label, international Phase III BREAK-3 (BRF113683) trial in 250 patients with previously untreated unresectable BRAF V600E mutation-positive metastatic stage III/IV melanoma showed that twice-daily 150 mg oral Tafinlar led to a...
BioCentury | Jun 3, 2013
Clinical News

Tafinlar dabrafenib: Interim Phase II data

Interim data from 13 evaluable NSCLC patients with V600 BRAF mutations who failed >=1 line of chemotherapy in the 2-stage, open-label, international Phase II BRF113928 trial showed that twice-daily 150 mg Tafinlar led to an...
BioCentury | Nov 21, 2011
Clinical News

GSK2118436: Completed Phase III enrollment

GlaxoSmithKline disclosed in its 3Q11 earnings that it completed enrollment of the open-label, international Phase III BRF113683 trial comparing 150 mg GSK2118436 twice daily vs. 1,000 mg/m 2 IV dacarbazine every 3 weeks in about...
BioCentury | Jan 31, 2011
Clinical News

GSK2118436: Phase III started

GlaxoSmithKline began the open-label, international Phase III BRF113683 trial to compare twice-daily 150 mg GSK2118436 vs. 1,000 mg/m 2 IV dacarbazine every 3 weeks in 200 treatment-naïve patients with mutant BRAF V600 advanced melanoma. Last...
BioCentury | Aug 19, 2010
Distillery Therapeutics

Indication: Cancer

...factor, BRF1-like (BRF2) A study in cell culture and in patient samples suggests that inhibiting BRF2...
...lung cancer. In an NSCLC squamous cell carcinoma cell line, small interfering RNA-mediated knockdown of BRF2...
...decreased cell proliferation compared with that seen using nontargeting siRNA. In human lung tissue samples, BRF2...
BioCentury | May 8, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Solid tumors RNA polymerase III (pol III); Brf1, a subunit of pol III transcription initiation factor IIIB A study in cell...
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