20:15 , Apr 30, 2019 |  BC Innovations  |  Distillery Therapeutics

BMP2/BMP6/activin A-based chimera for bone repair

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Cell culture and non-human primate studies identified chimera composed of BMP2, BMP6 and activin A sequences that could help repair bone.The chimera consists of human BMP2 engineered with substitutions...
18:50 , Nov 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Mouse studies suggest inhibiting BMP6 or promoting NOG expression could help treat cognitive dysfunction in AD. In a mouse model of AD, levels of BMP6 in the hippocampal dentate gyrus were...
22:24 , Jan 5, 2018 |  BioCentury  |  Finance

Scholar goes to the clinic

While Scholar Rock LLC’s series C round will bring the biotech’s lead program into the clinic, investors also want continued investment in the company’s growth factor modulation platform to maximize its value. On Jan. 3,...
16:54 , Jun 14, 2017 |  BC Innovations  |  Distillery Therapeutics

Musculoskeletal

INDICATION: Bone repair Pig studies suggest in situ ultrasound- and microbubble-mediated delivery of BMP6 gene therapy could help treat bone fractures. The therapy involved implanting a collagen scaffold at the fracture site to attract mesenchymal...
07:00 , Jul 16, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Peroxisome proliferation activated receptor (PPAR) γ

Musculoskeletal disease INDICATION: Osteoporosis Cell culture studies suggest an indole biphenyl carboxylic acid-based PPARγ antagonist could help treat osteoporosis. Optimization of a previously reported indole biphenyl carboxylic acid-based partial antagonist yielded an inverse agonist that...
08:00 , Nov 21, 2013 |  BC Innovations  |  Targets & Mechanisms

Getting to the root of periodontitis

Current periodontitis therapies do not target the underlying immune response that drives the disease. A team from the U.S. and Brazil is looking to change that and has shown that microparticles loaded with chemokine CC...
07:00 , Sep 1, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Bone repair Bone morphogenetic protein 6 (BMP6) Rat studies suggest porcine adipose tissue-derived stem cells expressing recombinant human BMP6 could help improve bone repair....
08:00 , Mar 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Hematology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Hematology Anemia; hemochromatosis Bone morphogenetic protein 6 (BMP6); hemochromatosis (HFE); hemochromatosis type 2 (juvenile) (HFE2); hepcidin antimicrobial peptide (HAMP) Two separate...