BC Innovations | Dec 19, 2019
Distillery Therapeutics

Skin grafts based on CRISPR-edited iPS cells to treat epidermolysis bullosa

DISEASE CATEGORY: Dermatology INDICATION: Blistering disorder Skin grafts based on CRISPR-edited induced pluripotent stem (iPS) cells could treat recessive dystrophic epidermolysis bullosa, a blistering disorder caused by mutations in COL7A1. Generation of the full-thickness grafts...
BC Innovations | Jul 18, 2017
Distillery Techniques

Disease models

TECHNOLOGY: 3-D models hPSC-derived lung bud organoids could be used to model pulmonary diseases. The organoids are generated by differentiating adherent hPSCs into anterior foregut endoderm by suspending detached clumps of the cells in a...
BC Innovations | Jul 12, 2017
Emerging Company Profile

Epigenetics: It’s personal

Stelvio Oncology is using the wide inter- and intra-tumoral diversity of glioblastoma multiforme (GBM) tumors to create a personalized medicine platform that drives GBM stem cells to adopt benign cell fates based on patient-specific epigenetic...
BC Innovations | May 31, 2017
Distillery Techniques

Disease models

TECHNOLOGY: 3-D models hPSC-derived inner ear organoids with functional hair cells could be used to screen therapies for inner ear diseases. The organoids were generated from human embryonic stem cells (hESCs) or induced pluripotent stem...
BC Innovations | Jan 11, 2017
Distillery Therapeutics

Dermatology

INDICATION: Scars / wrinkles Mouse and patient sample studies suggest BMP2 or BMP4 could help prevent or treat scars. Under culture conditions that promote adipocyte differentiation, dermal cells of wild-type mice taken from wounds containing...
BC Innovations | Dec 3, 2015
Distillery Therapeutics

Therapeutics: Heart and neural crest derivatives expressed 2 (HAND2); myocyte enhancer factor 2C (Mef2c); bone morphogenetic protein 4 (BMP4)

Cardiovascular disease INDICATION: Myocardial infarction (MI) Studies in cells and mice suggest a protein-based method for reprogramming human dermal fibroblasts into cardiac progenitor cells could help regenerate heart tissue after MI. In vitro, incubation of...
BC Innovations | Nov 19, 2015
Distillery Techniques

Techniques: Human pluripotent stem cell-derived kidney organoids for in vitro nephrotoxicity screening

Disease models TECHNOLOGY: 3D models Kidney organoids derived from human pluripotent stem cells could be used to screen compounds for nephrotoxicity. Human induced pluripotent stem (iPS) cells or embryonic stem cells (hESCs) sequentially exposed to...
BC Innovations | Sep 10, 2015
Distillery Techniques

Techniques: An ataxia telangiectasia mutated (ATM)-knockout mouse model of pancreatic ductal adenocarcinoma (PDAC)

Disease models bone morphogenetic protein 4 (BMP4) ataxia telangiectasia mutated...
BC Innovations | Nov 13, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Bone morphogenetic protein 4 (BMP4); BMP5; smoothened (SMO) Mouse studies suggest activating BMP4 and BMP5 signaling could help treat bladder cancer. In a...
BC Innovations | Nov 13, 2014
Tools & Techniques

Building blood vessels

A new way to build blood vessels for revascularizing ischemic tissues could be the upshot of a protocol designed by researchers at the Indiana University that generates mass quantities of endothelium-forming cells. 1 The protocol...
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