00:14 , Jun 4, 2019 |  BC Innovations  |  Distillery Therapeutics

BMP2- and lysostaphin-loaded hydrogel for bone repair, infection

DISEASE CATEGORY: Infectious disease; musculoskeletal INDICATION: Staphylococcus; bone repair Mouse studies suggest PEG-based hydrogel loaded with BMP2 and lysostaphin could help treat S. aureus infection due to implant contamination and help repair bone. The hydrogel,...
20:15 , Apr 30, 2019 |  BC Innovations  |  Distillery Therapeutics

BMP2/BMP6/activin A-based chimera for bone repair

DISEASE CATEGORY: Musculoskeletal INDICATION: Bone repair Cell culture and non-human primate studies identified chimera composed of BMP2, BMP6 and activin A sequences that could help repair bone.The chimera consists of human BMP2 engineered with substitutions...
01:46 , Feb 2, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Animal models; 3-D models Mice implanted with a 3-D bone marrow niche could be used to screen AML therapies. The model involved implanting mice with a 3-D niche consisting of a gelatin sponge seeded...
00:53 , Jan 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Dermatology

INDICATION: Scars / wrinkles Mouse and patient sample studies suggest BMP2 or BMP4 could help prevent or treat scars. Under culture conditions that promote adipocyte differentiation, dermal cells of wild-type mice taken from wounds containing...
07:00 , Oct 27, 2016 |  BC Innovations  |  Distillery Therapeutics

Musculoskeletal

INDICATION: Bone repair Non-human primate and rat studies showed that a synthetic hyperelastic bone scaffold could promote spinal fusion and treat skull bone loss. The hyperelastic bone scaffold consisted of 90% hydroxyapatite and 10% poly(lactic-co-glycolic...
07:00 , Oct 13, 2016 |  BC Innovations  |  Product R&D

Elastic bones

A group at Northwestern University has created a "hyperelastic bone" scaffold to address the need for a bone-inducing material that is easily manufactured, low cost and easy to manipulate during surgery. While the short-term goal...
08:00 , Feb 18, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Bone morphogenetic protein 2 (BMP2)

Cancer INDICATION: Ovarian cancer In vitro, patient sample and mouse studies suggest inhibiting BMP2 could help treat ovarian cancer. In human ovarian cancer cell lines and tumor samples from patients with ovarian cancer, BMP2 increased...
07:00 , Jul 16, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Peroxisome proliferation activated receptor (PPAR) γ

Musculoskeletal disease INDICATION: Osteoporosis Cell culture studies suggest an indole biphenyl carboxylic acid-based PPARγ antagonist could help treat osteoporosis. Optimization of a previously reported indole biphenyl carboxylic acid-based partial antagonist yielded an inverse agonist that...
07:00 , Jun 23, 2014 |  BC Week In Review  |  Company News

Fibrocell Science Inc, University of California deal

Under the 2011 deal, Fibrocell is providing UCLA with its cell multiplication and expansion technology to research diagnostics or treatments based on patients’ own cells, as well as funding (see BioCentury, March 14, 2011 &...
07:00 , Mar 27, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Bone repair; wounds Bone morphogenetic protein 2 (BMP2); platelet-derived growth factor BB (PDGFBB); placental growth factor (PGF; PlGF); VEGF receptor 2 (KDR/Flk-1; VEGFR-2) Rodent...