BioCentury | Jun 4, 2020
Finance

Everest to fund late-stage trials with $310M mountain of fresh cash

...for pulmonary arterial hypertension, under a deal with United Therapeutics Inc. (NASDAQ:UTHR); and IV broad-spectrum LACTB...
...Novartis AG (NYSE:NVS; SIX:NOVN). Targets FGFR4 (CD334) - Fibroblast growth factor receptor 4 LACTB - Beta lactamase...
BioCentury | Dec 20, 2019
Tools & Techniques

Editing bacterial resistance via gene drives

...Driving on Parallel Tracks” ). Hongjiang Li, Staff Writer University of California San Diego CRISPR-associated protein 9 (Cas9) Beta lactamase (LACTB) gene...
BioCentury | Aug 22, 2019
Distillery Therapeutics

Treating carbapenem-resistant bacteria with the insect-derived thanatin

DISEASE CATEGORY: Infectious disease INDICATION: Gram-negative bacterial infection; Escherichia Thanatin, a 21-residue insect peptide, could treat infections by Gram-negative bacteria producing the β-lactamase NDM-1. Thanatin reduced the growth of seven clinical NDM-1 producing E.coli and...
BioCentury | Jul 13, 2019
Product Development

Why Merck is in infectious disease for the long haul

...were failing their current antibacterial treatment. Zerbaxa, which contains a cephalosporin antibacterial and an irreversible beta lactamase...
...a July 16 PDUFA date to treat imipenem-resistant infections, is a class A and C beta lactamase...
BioCentury | Apr 16, 2019
Company News

Achaogen files for bankruptcy amid continued headwinds for antibiotic developers

...has C-Scape -- an oral combination of ceftibuten, a third-generation cephalosporin, and clavulanate, a beta lactamase (LACTB...
BioCentury | Apr 1, 2019
Emerging Company Profile

Arixa: Breaking resistance with oral beta lactamase inhibitors

...C LACTB that is in Phase I testing. VenatoRx Pharmaceuticals Inc.’s VNRX-7145 is a preclinical LACTB...
...VenatoRx Pharmaceuticals Inc., Malvern, Pa. Targets β-lactamase (LACTB) Sandi Wong, Staff Writer ARX-1796 Avibactam (NXL104, AVE1330A) Arixa Pharmaceuticals Inc. Beta lactamase (LACTB) Gram-negative...
BioCentury | Feb 7, 2019
Tools & Techniques

Virtual compound library for high throughput computational drug discovery

...Dopamine D4 receptor Sandi Wong UCSF University of California San Francisco University of North Carolina at Chapel Hill AmpC beta lactamase Dopamine...
BioCentury | Oct 26, 2018
Finance

Rempex remix

...sales of Vabomere, Orbactiv and Minocin. Qpex acquired preclinical infectious disease programs including β lactamase (LACTB...
...an investor in Mpex and Rempex. Virginia Li, Assistant Editor New Enterprise Associates Qpex Biopharma Inc. The Medicines Co. Beta lactamase (LACTB...
BioCentury | Oct 5, 2018
Company News

Boston Pharmaceuticals licenses three Novartis antibacterials, five GSK programs

...treat carbapenem-resistant Enterobacteriaceae (CRE) infections resistant to serine and/or metallo β lactamases (LACTBs); IID572, an LACTB...
...Pharmaceuticals Inc., Cambridge, Mass. Business: Pharmaceuticals Sandi Wong GSK3008356 GSK3183475 GSK3352589 IID572 LYS228 MAK181 Boston Pharmaceuticals Inc. GlaxoSmithKline plc Novartis AG Bacterial UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) Beta lactamase (LACTB) Diacylglycerol...
BioCentury | Oct 3, 2018
Company News

Boston Pharmaceuticals licenses three Novartis antibacterials, five GSK programs

...treat carbapenem-resistant Enterobacteriaceae (CRE) infections resistant to serine and/or metallo β lactamases (LACTBs); IID572, an LACTB...
...20-25 assets (see "Community Chorus" ). Sandi Wong Boston Pharmaceuticals Inc. GlaxoSmithKline plc Novartis AG Bacterial UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) Beta lactamase (LACTB) Diacylglycerol...
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