BioCentury | Jan 31, 2020
Distillery Therapeutics

Inhibiting SPK2 to treat Middle East respiratory syndrome

DISEASE CATEGORY: Infectious disease INDICATION: Coronavirus SKP2 inhibition could treat Middle East respiratory syndrome (MERS) coronavirus infection by reducing degradation of BECN, an autophagy regulator. In cell-based assays, MERS coronavirus infection induced SKP2 phosphorylation and...
BC Innovations | May 16, 2018
Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) In vitro and mouse studies suggest a peptide-based agent that captures Aβ 42 and induces autophagy could help treat AD. The “nanosweeper” agent consists of a PEGylated GKLVFF peptide that binds...
BC Extra | May 10, 2018
Preclinical News

‘Nanosweepers’ could degrade beta amyloid to treat Alzheimer’s

Researchers at Beijing’s National Center for Nanoscience and Technology and colleagues published a paper in Nature Communications describing a self-destructive "nanosweeper" based on multifunctional peptide-polymers that improved memory deficits after capturing and degrading extracellular deposits...
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