BioCentury | Mar 25, 2020
Product Development

COVID-19 roundup: Emergency use of Moderna vaccine could come earlier than expected; plus ASCO goes virtual, Galapagos pauses filgotinib trials and more

...able to prevent the spike from binding BSG. Reported by Fourth Military Medical University scientists, BSG...
BioCentury | Mar 20, 2020
Translation in Brief

Vaxxas' temperature-stable, low-dose vaccine patch; plus Stanford screen for 3-D tumor targets, new invasion mechanism for SARS-CoV-2 and PharmaMar

...to bind BSG. In a preprint published in bioRxiv , the team also showed that anti-BSG...
...similar multiplication and propagation mechanisms. Targets ACE2 - Angiotensin-converting enzyme 2 BSG (EMMPRIN; CD147) - Basigin Ok blood group...
...A virus hemagglutinin BioCentury Staff Bill & Melinda Gates Foundation PharmaMar S.A. Stanford University Influenza A virus hemagglutinin (Influenza A HA) Basigin Ok blood group (BSG) (EMMPRIN) (CD147) Eukaryotic...
BioCentury | May 8, 2017
Distillery Techniques

Disease models

...in 13 patients, including a missense mutation on BSG in one patient. Sequencing of the BSG...
...missense, nonsense and splicing BSG mutations. In mice, knock-in of one of the myopia-associated missense BSG...
...model to screen therapies. DESCRIPTION: Mouse model of early-onset high myopia expressing basigin Ok blood group (BSG; EMMPRIN; CD147...
BioCentury | Feb 2, 2017
Distillery Therapeutics

Infectious disease

...C-terminal fragment of wild-type P. falciparum Rh5 engineered to contain 18 point mutations, and bound BSG...
...with a K d of 0.41 µM. In thermal stability assays, the variant retained its BSG-binding...
...anti-malaria vaccines. TARGET/MARKER/PATHWAY: Plasmodium falciparum reticulocyte-binding protein homolog 5 (P. falciparum Rh5); basigin Ok blood group (BSG; EMMPRIN; CD147...
BioCentury | Nov 21, 2016
Strategy

LG’s biotech legacy

...mAb targeting CD147 in discovery. BioCentury’s BCIQ online database does not list any programs targeting CD147...
BioCentury | Sep 10, 2015
Distillery Therapeutics

Therapeutics: Basigin Ok blood group (BSG; EMMPRIN; CD147); P. falciparum reticulocyte-binding protein homolog 5 (PfRh5)

...decreased binding between BSG and the Plasmodium falciparum entry factor PfRh5 comparably to a high-affinity anti-BSG...
...P. falciparum invasion complex and their potential as therapeutic targets. TARGET/MARKER/PATHWAY: Basigin Ok blood group (BSG; EMMPRIN ; CD147...
BioCentury | Sep 22, 2014
Clinical News

Oleogel-S10: Phase III data

...the BSH-12 trial in patients with split-thickness skin graft donor site wounds (p<0.0001); and the BSG-12...
BioCentury | Jun 26, 2014
Distillery Therapeutics

Indication: Infectious disease

...Summary Licensing status Publication and contact information Infectious disease Bacterial infection; meningitis Basigin Ok blood group (BSG; EMMPRIN; CD147...
...their receptor CD147 could help prevent or treat meningococcal infections. In human endothelial cell cultures, CD147-specific...
...the pilin subunits did not. In ex vivo human brain tissue, wild-type N. meningitidis colonized CD147+...
BioCentury | Jun 26, 2014
Targets & Mechanisms

Managing meningitis

...meningitidis epitopes that interact with theirnewly identified human receptor- CD147 ( basigin Ok blood group ; BSG ; EMMPRIN...
...interacts with meningococcal pili. A series of cell line studies pinpointed CD147 as the receptor. CD147...
...is enhanced at sites of meningococcal adhesion. In human endothelial cells, CD147-specific siRNA or an anti-CD147...
BioCentury | Dec 1, 2011
Distillery Therapeutics

Indication: Infectious disease

...contact information Infectious disease Malaria Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRh5); basigin Ok blood group (BSG; EMMPRIN; CD147...
...In an in vitro screen, PfRh5 bound the receptor BSG on erythrocytes, suggesting that the PfRh5-BSG...
...cells and trigger clinical symptoms. In cell culture, anti-BSG mAbs or small hairpin RNA against BSG...
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